Fluorescent MUA-stabilized Au nanoclusters for sensitive and selective detection of penicillamine

Huan Yu; Xinfeng Chen; Long Yu; Mingtai Sun; Khalid A. Alamry; Abdullah M. Asiri; Kui Zhang; Juan Antonio Zapien; Suhua Wang

doi:10.1007/s00216-018-0936-7

Fluorescent MUA-stabilized Au nanoclusters for sensitive and selective detection of penicillamine

Huan Yu
, Xinfeng Chen
, Long Yu
, Mingtai Sun
, Khalid A. Alamry
, Abdullah M. Asiri
, Kui Zhang^*
, Juan Antonio Zapien
, Suhua Wang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

26 Citations (Scopus)

Abstract

In this study, we have developed a facile method for preparation of highly fluorescent Au nanoclusters (AuNCs) using 11-mercaptoundecanoic acid (MUA) as both the reducing and stabilizing agent. The as-prepared MUA functionalized AuNCs (MUA-AuNCs) have good water solubility, excellent photostability, and strong fluorescence emission at 610 nm with a quantum yield of 7.28% in water. The fluorescence of MUA-AuNCs was first quenched by copper ions through electron transfer, subsequently caused obvious restoration by competitive effect after adding penicillamine, making it a potential fluorescent sensor for penicillamine with a detection limit of 0.08 μM. Furthermore, the newly designed fluorescence "on-off-on" assay was explored for the measurement of penicillamine in complex real water and urine samples with satisfactory results.

Original language	English
Pages (from-to)	2629-2636
Journal	Analytical and Bioanalytical Chemistry
Volume	410
Issue number	10
Online published	10 Feb 2018
DOIs	https://doi.org/10.1007/s00216-018-0936-7
Publication status	Published - Apr 2018

Research Keywords

11-Mercaptoundecanoic acid
Au nanoclusters
Copper
Penicillamine
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title = "Fluorescent MUA-stabilized Au nanoclusters for sensitive and selective detection of penicillamine",

abstract = "In this study, we have developed a facile method for preparation of highly fluorescent Au nanoclusters (AuNCs) using 11-mercaptoundecanoic acid (MUA) as both the reducing and stabilizing agent. The as-prepared MUA functionalized AuNCs (MUA-AuNCs) have good water solubility, excellent photostability, and strong fluorescence emission at 610 nm with a quantum yield of 7.28\% in water. The fluorescence of MUA-AuNCs was first quenched by copper ions through electron transfer, subsequently caused obvious restoration by competitive effect after adding penicillamine, making it a potential fluorescent sensor for penicillamine with a detection limit of 0.08 μM. Furthermore, the newly designed fluorescence {"}on-off-on{"} assay was explored for the measurement of penicillamine in complex real water and urine samples with satisfactory results.",

keywords = "11-Mercaptoundecanoic acid, Au nanoclusters, Copper, Penicillamine, Turn on",

author = "Huan Yu and Xinfeng Chen and Long Yu and Mingtai Sun and Alamry, \{Khalid A.\} and Asiri, \{Abdullah M.\} and Kui Zhang and Zapien, \{Juan Antonio\} and Suhua Wang",

year = "2018",

month = apr,

doi = "10.1007/s00216-018-0936-7",

language = "English",

volume = "410",

pages = "2629--2636",

journal = "Analytical and Bioanalytical Chemistry",

issn = "1618-2642",

publisher = "Springer Science and Business Media Deutschland GmbH",

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TY - JOUR

T1 - Fluorescent MUA-stabilized Au nanoclusters for sensitive and selective detection of penicillamine

AU - Yu, Huan

AU - Chen, Xinfeng

AU - Yu, Long

AU - Sun, Mingtai

AU - Alamry, Khalid A.

AU - Asiri, Abdullah M.

AU - Zhang, Kui

AU - Zapien, Juan Antonio

AU - Wang, Suhua

PY - 2018/4

Y1 - 2018/4

N2 - In this study, we have developed a facile method for preparation of highly fluorescent Au nanoclusters (AuNCs) using 11-mercaptoundecanoic acid (MUA) as both the reducing and stabilizing agent. The as-prepared MUA functionalized AuNCs (MUA-AuNCs) have good water solubility, excellent photostability, and strong fluorescence emission at 610 nm with a quantum yield of 7.28% in water. The fluorescence of MUA-AuNCs was first quenched by copper ions through electron transfer, subsequently caused obvious restoration by competitive effect after adding penicillamine, making it a potential fluorescent sensor for penicillamine with a detection limit of 0.08 μM. Furthermore, the newly designed fluorescence "on-off-on" assay was explored for the measurement of penicillamine in complex real water and urine samples with satisfactory results.

AB - In this study, we have developed a facile method for preparation of highly fluorescent Au nanoclusters (AuNCs) using 11-mercaptoundecanoic acid (MUA) as both the reducing and stabilizing agent. The as-prepared MUA functionalized AuNCs (MUA-AuNCs) have good water solubility, excellent photostability, and strong fluorescence emission at 610 nm with a quantum yield of 7.28% in water. The fluorescence of MUA-AuNCs was first quenched by copper ions through electron transfer, subsequently caused obvious restoration by competitive effect after adding penicillamine, making it a potential fluorescent sensor for penicillamine with a detection limit of 0.08 μM. Furthermore, the newly designed fluorescence "on-off-on" assay was explored for the measurement of penicillamine in complex real water and urine samples with satisfactory results.

KW - 11-Mercaptoundecanoic acid

KW - Au nanoclusters

KW - Copper

KW - Penicillamine

KW - Turn on

UR - https://www.scopus.com/pages/publications/85041898294

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85041898294&origin=recordpage

U2 - 10.1007/s00216-018-0936-7

DO - 10.1007/s00216-018-0936-7

M3 - RGC 21 - Publication in refereed journal

SN - 1618-2642

VL - 410

SP - 2629

EP - 2636

JO - Analytical and Bioanalytical Chemistry

JF - Analytical and Bioanalytical Chemistry

IS - 10

ER -

Fluorescent MUA-stabilized Au nanoclusters for sensitive and selective detection of penicillamine

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