Fluorescence characteristic study of the ternary complex of fluoroquinolone antibiotics and cobalt (II) with ATP

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

19 Scopus Citations
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Author(s)

  • S. Wu
  • X. Chen
  • Z. Hu
  • M. Hooper
  • B. Hooper
  • Z. Zhao

Detail(s)

Original languageEnglish
Pages (from-to)1317-1323
Journal / PublicationSpectrochimica Acta - Part A Molecular and Biomolecular Spectroscopy
Volume57
Issue number6
Publication statusPublished - 2001
Externally publishedYes

Abstract

The results from the measurement of the fluorescence spectra of fluoroquinolone antibiotics including ofloxacin (OF), norfloxacin (NOR) and ciprofloxacin (CIP) complexed with cobalt (II) and ATP give information concerning the antibiotics-nucleotide interactions. From the fluorescence spectral data, it appears that the fluoroquinolone antibiotic cannot directly complex with ATP but indirectly complex with cobalt (II), which is playing an intermediary role. The interaction of fluoroquinolone antibiotic with the nucleotide occurs mainly through the phosphate group. The conclusion offers a more complete mechanism, which is important for understanding the interaction of these drugs with DNA. © 2001 Elsevier Science B.V.

Research Area(s)

  • ATP, Cobalt (II), Fluorescence, Fluoroquinolone antibiotics

Citation Format(s)

Fluorescence characteristic study of the ternary complex of fluoroquinolone antibiotics and cobalt (II) with ATP. / Wu, S.; Zhang, W.; Chen, X.; Hu, Z.; Hooper, M.; Hooper, B.; Zhao, Z.

In: Spectrochimica Acta - Part A Molecular and Biomolecular Spectroscopy, Vol. 57, No. 6, 2001, p. 1317-1323.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review