Flexible Surface-Enhanced Raman Scattering Chip : A Universal Platform for Real-Time Interfacial Molecular Analysis with Femtomolar Sensitivity

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

6 Scopus Citations
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Author(s)

  • Qi Hao
  • Mingze Li
  • Jiawei Wang
  • Xingce Fan
  • Jie Jiang
  • Xiaoxia Wang
  • Teng Qiu
  • Libo Ma
  • Oliver G. Schmidt

Detail(s)

Original languageEnglish
Pages (from-to)54174–54180
Number of pages7
Journal / PublicationACS Applied Materials and Interfaces
Volume12
Issue number48
Online published18 Nov 2020
Publication statusPublished - 2 Dec 2020

Abstract

We propose and demonstrate a flexible surface-enhanced Raman scattering (SERS) chip as a versatile platform for femtomolar detection and real-time interfacial molecule analysis. The flexible SERS chip is composed of a flexible and transparent membrane and embedded plasmonic dimers with ultrahigh particle density and ultrasmall dimer gap. The chip enables rapid identification for residuals on solid substrates with irregular surfaces or dissolved analytes in aqueous solution. The sensitivity for liquid-state measurement is down to 0.06 molecule per dimers for 10-14 mol·L-1 Rhodamine 6G molecule without molecule enrichment. Strong signal fluctuation and blinking are observed at this concentration, indicating that the detection limit is close to the single-molecule level. Meanwhile, the homogeneous liquid environment facilities accurate SERS quantification of analytes with a wide dynamic range. The synergy of flexibility and liquid-state measurement opens up avenues for the real-time study of chemical reactions. The reduction from p-nitrothiophenol (PNTP) to p-aminothiophenol (PATP) in the absence of the chemical reducing agents is observed at liquid interfaces by in situ SERS measurements, and the plasmon-induced hot electron is demonstrated to drive the catalytic reaction. We believe this robust and feasible approach is promising in extending the SERS technique as a general method for identifying interfacial molecular traces, tracking the evolution of heterogeneous reactions, elucidating the reaction mechanisms, and evaluating the environmental effects such as pH value and salty ions in SERS.

Research Area(s)

  • dimers, flexible membrane, liquid state, plasmonics, quantitative analysis, surface-enhanced Raman scattering

Citation Format(s)

Flexible Surface-Enhanced Raman Scattering Chip : A Universal Platform for Real-Time Interfacial Molecular Analysis with Femtomolar Sensitivity. / Hao, Qi; Li, Mingze; Wang, Jiawei; Fan, Xingce; Jiang, Jie; Wang, Xiaoxia; Zhu, Minshen; Qiu, Teng; Ma, Libo; Chu, Paul K.; Schmidt, Oliver G.

In: ACS Applied Materials and Interfaces, Vol. 12, No. 48, 02.12.2020, p. 54174–54180.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review