First examples of luminescent cyclometalated iridium(III) complexes as labeling reagents for biological substrates

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)4999-5001
Journal / PublicationOrganometallics
Volume20
Issue number24
Publication statusPublished - 26 Nov 2001

Abstract

The syntheses, and photophysical and electrochemical properties of the three luminescent cyclometalated iridium(III) complexes [Ir(ppy)2(phen-NCS)](PF6) (1), [Ir(ppy)2(phen-NHCOCH2I)](PF6) (2), and [Ir(ppy)2(phen-NH2)](PF6) (3) (ppy- = 2-phenylpyridinate anion, phen-NCS = 5-isothiocyanato-1,10-phenanthroline, phen-NHCOCH2I = 5-(iodoacetamido)-1,10-phenanthroline, phen-NH2 = 5-amino-1,10-phenanthroline) are reported. Since the isothiocyanate and iodoacetamide groups can react with the primary amine and sulfhydryl groups of biomolecules, respectively, complexes 1 and 2 have been used to label amine- or sulfhydryl-modified oligonucleotides, and human serum albumin, to give luminescent bioconjugates.

Citation Format(s)

First examples of luminescent cyclometalated iridium(III) complexes as labeling reagents for biological substrates. / Lo, Kenneth Kam-Wing; Ng, Dominic Chun-Ming; Chung, Chi-Keung.
In: Organometallics, Vol. 20, No. 24, 26.11.2001, p. 4999-5001.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review