Finnish prenatal study of autism and autism spectrum disorders (FIPS-A) : Overview and design

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Katja M. Lampi
  • P. Nina Banerjee
  • Mika Gissler
  • Susanna Hinkka-Yli-Salomäki
  • Jukka Huttunen
  • Ulla Kulmala
  • Jarna Lindroos
  • Solja Niemelä
  • Maria Rihko
  • Terja Ristkari
  • Kristiina Saanakorpi
  • Tanja Sarlin
  • Lauri Sillanmäki
  • Heljä-Marja Surcel
  • Hans Helenius
  • Alan S. Brown
  • Andre Sourander

Detail(s)

Original languageEnglish
Pages (from-to)1090-1096
Journal / PublicationJournal of Autism and Developmental Disorders
Volume41
Issue number8
Publication statusPublished - Aug 2011
Externally publishedYes

Abstract

This article presents an overview of the Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A), a new study designed to examine the relationship between prenatal serologic factors, mediating and moderating developmental antecedents, and risk of autism spectrum disorders (ASD). The FIPS-A is based on register linkages between births from 1987 to 2005 ascertained from the Finnish Medical Birth Register (FMBR) and other national registers on treatment for this group of disorders. All subjects were members of the Finnish Maternity Cohort (FMC), which consists of virtually all births in Finland from 1983 to the present, and which includes archived maternal serum samples. This study also capitalizes on other registry information, such as systematically collected data on pregnancy, prenatal and neonatal complications and manual data collection from well-child clinics providing developmental data from birth to the age of 7 years. In this paper, we describe the methods used in the FIPS-A study, including a description of the national registers, available data and case ascertainment procedures. Finally, we discuss implications of the data for future work on uncovering putative aetiologies of ASD and key strengths and limitations of the design. © 2010 Springer Science+Business Media, LLC.

Research Area(s)

  • Autism, Epidemiology, Methodology, Prenatal risk factors, Register study

Bibliographic Note

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Citation Format(s)

Finnish prenatal study of autism and autism spectrum disorders (FIPS-A) : Overview and design. / Lampi, Katja M.; Banerjee, P. Nina; Gissler, Mika; Hinkka-Yli-Salomäki, Susanna; Huttunen, Jukka; Kulmala, Ulla; Lindroos, Jarna; Niemelä, Solja; Rihko, Maria; Ristkari, Terja; Saanakorpi, Kristiina; Sarlin, Tanja; Sillanmäki, Lauri; McKeague, Ian W.; Surcel, Heljä-Marja; Helenius, Hans; Brown, Alan S.; Sourander, Andre.

In: Journal of Autism and Developmental Disorders, Vol. 41, No. 8, 08.2011, p. 1090-1096.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review