Fibro-Gel: An All-Aqueous Hydrogel Consisting of Microfibers with Tunable Release Profile and its Application in Wound Healing

Yanting Shen; Yuan Liu; Janine K. Nunes; Chenmin Wang; Miao Xu; Michael K.T. To; Howard A. Stone; Ho Cheung Shum

doi:10.1002/adma.202211637

Fibro-Gel: An All-Aqueous Hydrogel Consisting of Microfibers with Tunable Release Profile and its Application in Wound Healing

Yanting Shen (Co-first Author)
, Yuan Liu (Co-first Author)
, Janine K. Nunes
, Chenmin Wang
, Miao Xu
, Michael K.T. To^*
, Howard A. Stone^*
, Ho Cheung Shum^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

57 Citations (Scopus)

30 Downloads (CityUHK Scholars)

Abstract

Injectable hydrogels are valuable tools in tissue engineering and regenerative medicine due to their unique advantages of injectability with minimal invasiveness and usability for irregularly shaped sites. However, it remains challenging to achieve scalable manufacturing together with matching physicochemical properties and on-demand drug release for a high level of control over biophysical and biomedical cues to direct endogenous cells. Here, the use of an injectable fibro-gel is demonstrated, a water-filled network of entangled hydrogel microfibers, whose physicochemical properties and drug release profiles can be tailored to overcome these shortcomings. This fibro-gel exhibits favorable in vitro biocompatibility and the capability to aid vascularization. The potential use of the fibro-gel for advancing tissue regeneration is explored with a mice excision skin model. Preliminary in vivo tests indicate that the fibro-gel promotes wound healing and new healthy tissue regeneration at a faster rate than a commercial gel. Moreover, it is demonstrated that the release of distinct drugs at different rates can further accelerate wound healing with higher efficiency, by using a two-layer fibro-gel model. The combination of injectability and tailorable properties of this fibro-gel offers a promising approach in biomedical fields such as therapeutic delivery, medical dressings, and 3D tissue scaffolds for tissue engineering. © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.

Original language	English
Article number	2211637
Journal	Advanced Materials
Volume	35
Issue number	19
Online published	15 Feb 2023
DOIs	https://doi.org/10.1002/adma.202211637
Publication status	Published - 11 May 2023
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This project is supported by Research Grant Council of Hong Kong through the Research Impact Fund (No. R7072-18), with H.C.S. as the Project Coordinator, and J.K.N., H.A.S., and M.K.T.T. as co-principal-investigators under a collaborative project. This research is partially supported by the Health@InnoHK program of the Innovation and Technology Commission of the Hong Kong SAR Government as well as by NSF through the Princeton University (PCCM) Materials Research Science and Enigneering Center DMR-2011750.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Research Keywords

biomaterials
drug deliveries
injectable hydrogels
microfluidics
wound healing

Publisher's Copyright Statement

This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

RGC Funding Information

RGC-funded

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10.1002/adma.202211637

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@article{38300745180f47279683716dc6f3c544,

title = "Fibro-Gel: An All-Aqueous Hydrogel Consisting of Microfibers with Tunable Release Profile and its Application in Wound Healing",

abstract = "Injectable hydrogels are valuable tools in tissue engineering and regenerative medicine due to their unique advantages of injectability with minimal invasiveness and usability for irregularly shaped sites. However, it remains challenging to achieve scalable manufacturing together with matching physicochemical properties and on-demand drug release for a high level of control over biophysical and biomedical cues to direct endogenous cells. Here, the use of an injectable fibro-gel is demonstrated, a water-filled network of entangled hydrogel microfibers, whose physicochemical properties and drug release profiles can be tailored to overcome these shortcomings. This fibro-gel exhibits favorable in vitro biocompatibility and the capability to aid vascularization. The potential use of the fibro-gel for advancing tissue regeneration is explored with a mice excision skin model. Preliminary in vivo tests indicate that the fibro-gel promotes wound healing and new healthy tissue regeneration at a faster rate than a commercial gel. Moreover, it is demonstrated that the release of distinct drugs at different rates can further accelerate wound healing with higher efficiency, by using a two-layer fibro-gel model. The combination of injectability and tailorable properties of this fibro-gel offers a promising approach in biomedical fields such as therapeutic delivery, medical dressings, and 3D tissue scaffolds for tissue engineering. {\textcopyright} 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.",

keywords = "biomaterials, drug deliveries, injectable hydrogels, microfluidics, wound healing",

author = "Yanting Shen and Yuan Liu and Nunes, \{Janine K.\} and Chenmin Wang and Miao Xu and To, \{Michael K.T.\} and Stone, \{Howard A.\} and Shum, \{Ho Cheung\}",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].",

year = "2023",

month = may,

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language = "English",

volume = "35",

journal = "Advanced Materials",

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Fibro-Gel: An All-Aqueous Hydrogel Consisting of Microfibers with Tunable Release Profile and its Application in Wound Healing. / Shen, Yanting (Co-first Author); Liu, Yuan (Co-first Author); Nunes, Janine K. et al.
In: Advanced Materials, Vol. 35, No. 19, 2211637, 11.05.2023.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Fibro-Gel

T2 - An All-Aqueous Hydrogel Consisting of Microfibers with Tunable Release Profile and its Application in Wound Healing

AU - Shen, Yanting

AU - Liu, Yuan

AU - Nunes, Janine K.

AU - Wang, Chenmin

AU - Xu, Miao

AU - To, Michael K.T.

AU - Stone, Howard A.

AU - Shum, Ho Cheung

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2023/5/11

Y1 - 2023/5/11

N2 - Injectable hydrogels are valuable tools in tissue engineering and regenerative medicine due to their unique advantages of injectability with minimal invasiveness and usability for irregularly shaped sites. However, it remains challenging to achieve scalable manufacturing together with matching physicochemical properties and on-demand drug release for a high level of control over biophysical and biomedical cues to direct endogenous cells. Here, the use of an injectable fibro-gel is demonstrated, a water-filled network of entangled hydrogel microfibers, whose physicochemical properties and drug release profiles can be tailored to overcome these shortcomings. This fibro-gel exhibits favorable in vitro biocompatibility and the capability to aid vascularization. The potential use of the fibro-gel for advancing tissue regeneration is explored with a mice excision skin model. Preliminary in vivo tests indicate that the fibro-gel promotes wound healing and new healthy tissue regeneration at a faster rate than a commercial gel. Moreover, it is demonstrated that the release of distinct drugs at different rates can further accelerate wound healing with higher efficiency, by using a two-layer fibro-gel model. The combination of injectability and tailorable properties of this fibro-gel offers a promising approach in biomedical fields such as therapeutic delivery, medical dressings, and 3D tissue scaffolds for tissue engineering. © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.

AB - Injectable hydrogels are valuable tools in tissue engineering and regenerative medicine due to their unique advantages of injectability with minimal invasiveness and usability for irregularly shaped sites. However, it remains challenging to achieve scalable manufacturing together with matching physicochemical properties and on-demand drug release for a high level of control over biophysical and biomedical cues to direct endogenous cells. Here, the use of an injectable fibro-gel is demonstrated, a water-filled network of entangled hydrogel microfibers, whose physicochemical properties and drug release profiles can be tailored to overcome these shortcomings. This fibro-gel exhibits favorable in vitro biocompatibility and the capability to aid vascularization. The potential use of the fibro-gel for advancing tissue regeneration is explored with a mice excision skin model. Preliminary in vivo tests indicate that the fibro-gel promotes wound healing and new healthy tissue regeneration at a faster rate than a commercial gel. Moreover, it is demonstrated that the release of distinct drugs at different rates can further accelerate wound healing with higher efficiency, by using a two-layer fibro-gel model. The combination of injectability and tailorable properties of this fibro-gel offers a promising approach in biomedical fields such as therapeutic delivery, medical dressings, and 3D tissue scaffolds for tissue engineering. © 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.

KW - biomaterials

KW - drug deliveries

KW - injectable hydrogels

KW - microfluidics

KW - wound healing

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DO - 10.1002/adma.202211637

M3 - RGC 21 - Publication in refereed journal

C2 - 36789886

SN - 0935-9648

VL - 35

JO - Advanced Materials

JF - Advanced Materials

IS - 19

M1 - 2211637

ER -

Fibro-Gel: An All-Aqueous Hydrogel Consisting of Microfibers with Tunable Release Profile and its Application in Wound Healing

Abstract

Bibliographical note

Funding

UN SDGs

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

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