FeS/CeO2/Curcumin heterojunction for infectious arthritis therapy through synergistic sonodynamic-H2S and ultrasound modulated nanozyme as well as osteogenesis

Yu-Lin Lin; Tao Huang; Li-Man Liang; Rui Huang; Ai-Jing Zhao; Yi Zhang; Jin-Yang Xie; Li-Chang Tan; Yuan-Xing Huang; Jia-Qiao Yan; Jie-Ni Fu; Yong-Ying Li; Hao-Qi Li; Rui-Ke Zhang; Yuan Li; Zhi-Gang Chen; Hong-Bo Wu

doi:10.1007/s12598-025-03606-2

FeS/CeO₂/Curcumin heterojunction for infectious arthritis therapy through synergistic sonodynamic-H₂S and ultrasound modulated nanozyme as well as osteogenesis

Yu-Lin Lin (Co-first Author)
, Tao Huang (Co-first Author)
, Li-Man Liang (Co-first Author)
, Rui Huang
, Ai-Jing Zhao
, Yi Zhang
, Jin-Yang Xie
, Li-Chang Tan
, Yuan-Xing Huang
, Jia-Qiao Yan
, Jie-Ni Fu^*
, Yong-Ying Li
, Hao-Qi Li
, Rui-Ke Zhang
, Yuan Li^*
, Zhi-Gang Chen^*
, Hong-Bo Wu^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

4 Citations (Scopus)

Abstract

The treatment of infectious arthritis faces multiple challenges, including the exacerbation of traditional antibiotic resistance and the difficulty of regulating the tissue microenvironment. In this study, the FeS/CeO₂/Cur (curcumin) heterostructure was constructed through interface engineering, and an ultrasonic (US) responsive nanotherapeutic platform was proposed, which combined sonodynamic-H₂S antibacterial action with US modulated nanozyme activity. FeS/CeO₂/Cur integrated the intrinsic redox properties of Ce³⁺/Ce⁴⁺ with the piezoelectric catalytic effect. Under US irradiation, FeS/CeO₂/Cur nanozyme exhibited an interface-enhanced piezoelectric effect. It generated ·O₂⁻ and ·¹O₂ radicals through piezoelectric catalytic activity, while achieving the US-responsive release of H2S. The Ce³⁺/Ce⁴⁺ dynamic equilibrium system triggered shows US modulated antioxidant properties, which can scavenge pathogenic ROS by Ce³⁺/Ce⁴⁺ redox cycling during the interface. FeS/CeO₂/Cur's sonodynamic antibacterial activity revealed that it achieved broad-spectrum sterilization by disrupting bacterial ATP metabolism and regulating related genes, including narG, purM, and narJ. The in vivo bacterial arthritis model also confirmed that FeS/CeO₂/Cur can eliminate bacteria rapidly and promote osteogenic differentiation, providing an effective treatment strategy for infectious arthritis. © Youke Publishing Co., Ltd. 2025.

Original language	English
Pages (from-to)	10429-10447
Number of pages	19
Journal	Rare Metals
Volume	44
Issue number	12
Online published	16 Oct 2025
DOIs	https://doi.org/10.1007/s12598-025-03606-2
Publication status	Published - Dec 2025

Funding

This work was financially supported by the National Natural Science Foundation of China (No. 82402769), the Grant of State Key Laboratory of Respiratory Disease (No. SKLRD-Z-202511), the State-sponsored Postdoctoral Researcher program (No. GZB20230178), and China Postdoctoral Science Foundation (No. 2024M760643).

Research Keywords

Antimicrobial
Arthritis
Bone formation
Heterojunction
Piezoelectric

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10.1007/s12598-025-03606-2

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Cite this

Lin, Y.-L., Huang, T., Liang, L.-M., Huang, R., Zhao, A.-J., Zhang, Y., Xie, J.-Y., Tan, L.-C., Huang, Y.-X., Yan, J.-Q., Fu, J.-N., Li, Y.-Y., Li, H.-Q., Zhang, R.-K., Li, Y., Chen, Z.-G., & Wu, H.-B. (2025). FeS/CeO₂/Curcumin heterojunction for infectious arthritis therapy through synergistic sonodynamic-H₂S and ultrasound modulated nanozyme as well as osteogenesis. Rare Metals, 44(12), 10429-10447. https://doi.org/10.1007/s12598-025-03606-2

@article{e3211c9e388648c29a7176abc6a09645,

title = "FeS/CeO2/Curcumin heterojunction for infectious arthritis therapy through synergistic sonodynamic-H2S and ultrasound modulated nanozyme as well as osteogenesis",

abstract = "The treatment of infectious arthritis faces multiple challenges, including the exacerbation of traditional antibiotic resistance and the difficulty of regulating the tissue microenvironment. In this study, the FeS/CeO2/Cur (curcumin) heterostructure was constructed through interface engineering, and an ultrasonic (US) responsive nanotherapeutic platform was proposed, which combined sonodynamic-H2S antibacterial action with US modulated nanozyme activity. FeS/CeO2/Cur integrated the intrinsic redox properties of Ce3+/Ce4+ with the piezoelectric catalytic effect. Under US irradiation, FeS/CeO2/Cur nanozyme exhibited an interface-enhanced piezoelectric effect. It generated ·O2− and ·1O2 radicals through piezoelectric catalytic activity, while achieving the US-responsive release of H2S. The Ce3+/Ce4+ dynamic equilibrium system triggered shows US modulated antioxidant properties, which can scavenge pathogenic ROS by Ce3+/Ce4+ redox cycling during the interface. FeS/CeO2/Cur's sonodynamic antibacterial activity revealed that it achieved broad-spectrum sterilization by disrupting bacterial ATP metabolism and regulating related genes, including narG, purM, and narJ. The in vivo bacterial arthritis model also confirmed that FeS/CeO2/Cur can eliminate bacteria rapidly and promote osteogenic differentiation, providing an effective treatment strategy for infectious arthritis. {\textcopyright} Youke Publishing Co., Ltd. 2025.",

keywords = "Antimicrobial, Arthritis, Bone formation, Heterojunction, Piezoelectric",

author = "Yu-Lin Lin and Tao Huang and Li-Man Liang and Rui Huang and Ai-Jing Zhao and Yi Zhang and Jin-Yang Xie and Li-Chang Tan and Yuan-Xing Huang and Jia-Qiao Yan and Jie-Ni Fu and Yong-Ying Li and Hao-Qi Li and Rui-Ke Zhang and Yuan Li and Zhi-Gang Chen and Hong-Bo Wu",

year = "2025",

month = dec,

doi = "10.1007/s12598-025-03606-2",

language = "English",

volume = "44",

pages = "10429--10447",

journal = "Rare Metals",

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Lin, Y-L, Huang, T, Liang, L-M, Huang, R, Zhao, A-J, Zhang, Y, Xie, J-Y, Tan, L-C, Huang, Y-X, Yan, J-Q, Fu, J-N, Li, Y-Y, Li, H-Q, Zhang, R-K, Li, Y, Chen, Z-G & Wu, H-B 2025, 'FeS/CeO₂/Curcumin heterojunction for infectious arthritis therapy through synergistic sonodynamic-H₂S and ultrasound modulated nanozyme as well as osteogenesis', Rare Metals, vol. 44, no. 12, pp. 10429-10447. https://doi.org/10.1007/s12598-025-03606-2

FeS/CeO₂/Curcumin heterojunction for infectious arthritis therapy through synergistic sonodynamic-H₂S and ultrasound modulated nanozyme as well as osteogenesis. / Lin, Yu-Lin (Co-first Author); Huang, Tao (Co-first Author); Liang, Li-Man (Co-first Author) et al.
In: Rare Metals, Vol. 44, No. 12, 12.2025, p. 10429-10447.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - FeS/CeO2/Curcumin heterojunction for infectious arthritis therapy through synergistic sonodynamic-H2S and ultrasound modulated nanozyme as well as osteogenesis

AU - Lin, Yu-Lin

AU - Huang, Tao

AU - Liang, Li-Man

AU - Huang, Rui

AU - Zhao, Ai-Jing

AU - Zhang, Yi

AU - Xie, Jin-Yang

AU - Tan, Li-Chang

AU - Huang, Yuan-Xing

AU - Yan, Jia-Qiao

AU - Fu, Jie-Ni

AU - Li, Yong-Ying

AU - Li, Hao-Qi

AU - Zhang, Rui-Ke

AU - Li, Yuan

AU - Chen, Zhi-Gang

AU - Wu, Hong-Bo

PY - 2025/12

Y1 - 2025/12

N2 - The treatment of infectious arthritis faces multiple challenges, including the exacerbation of traditional antibiotic resistance and the difficulty of regulating the tissue microenvironment. In this study, the FeS/CeO2/Cur (curcumin) heterostructure was constructed through interface engineering, and an ultrasonic (US) responsive nanotherapeutic platform was proposed, which combined sonodynamic-H2S antibacterial action with US modulated nanozyme activity. FeS/CeO2/Cur integrated the intrinsic redox properties of Ce3+/Ce4+ with the piezoelectric catalytic effect. Under US irradiation, FeS/CeO2/Cur nanozyme exhibited an interface-enhanced piezoelectric effect. It generated ·O2− and ·1O2 radicals through piezoelectric catalytic activity, while achieving the US-responsive release of H2S. The Ce3+/Ce4+ dynamic equilibrium system triggered shows US modulated antioxidant properties, which can scavenge pathogenic ROS by Ce3+/Ce4+ redox cycling during the interface. FeS/CeO2/Cur's sonodynamic antibacterial activity revealed that it achieved broad-spectrum sterilization by disrupting bacterial ATP metabolism and regulating related genes, including narG, purM, and narJ. The in vivo bacterial arthritis model also confirmed that FeS/CeO2/Cur can eliminate bacteria rapidly and promote osteogenic differentiation, providing an effective treatment strategy for infectious arthritis. © Youke Publishing Co., Ltd. 2025.

AB - The treatment of infectious arthritis faces multiple challenges, including the exacerbation of traditional antibiotic resistance and the difficulty of regulating the tissue microenvironment. In this study, the FeS/CeO2/Cur (curcumin) heterostructure was constructed through interface engineering, and an ultrasonic (US) responsive nanotherapeutic platform was proposed, which combined sonodynamic-H2S antibacterial action with US modulated nanozyme activity. FeS/CeO2/Cur integrated the intrinsic redox properties of Ce3+/Ce4+ with the piezoelectric catalytic effect. Under US irradiation, FeS/CeO2/Cur nanozyme exhibited an interface-enhanced piezoelectric effect. It generated ·O2− and ·1O2 radicals through piezoelectric catalytic activity, while achieving the US-responsive release of H2S. The Ce3+/Ce4+ dynamic equilibrium system triggered shows US modulated antioxidant properties, which can scavenge pathogenic ROS by Ce3+/Ce4+ redox cycling during the interface. FeS/CeO2/Cur's sonodynamic antibacterial activity revealed that it achieved broad-spectrum sterilization by disrupting bacterial ATP metabolism and regulating related genes, including narG, purM, and narJ. The in vivo bacterial arthritis model also confirmed that FeS/CeO2/Cur can eliminate bacteria rapidly and promote osteogenic differentiation, providing an effective treatment strategy for infectious arthritis. © Youke Publishing Co., Ltd. 2025.

KW - Antimicrobial

KW - Arthritis

KW - Bone formation

KW - Heterojunction

KW - Piezoelectric

UR - https://www.scopus.com/pages/publications/105019109385

UR - https://www.scopus.com/pages/publications/105019109385#tab=impact

U2 - 10.1007/s12598-025-03606-2

DO - 10.1007/s12598-025-03606-2

M3 - RGC 21 - Publication in refereed journal

SN - 1001-0521

VL - 44

SP - 10429

EP - 10447

JO - Rare Metals

JF - Rare Metals

IS - 12

ER -