Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Author(s)

  • Pan Sun
  • Luyang Zhao
  • Xuehai Yan
  • Dennis K. P. Ng

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)23428-23438
Journal / PublicationAngewandte Chemie
Volume132
Issue number51
Online published3 Sept 2020
Publication statusPublished - 14 Dec 2020

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-85134879978&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(7febe671-273a-4b63-b9f7-72e48fbdea50).html

Abstract

A facile approach to assemble catalase-like photosensitizing nanozymes with a self-oxygen-supplying ability was developed. The process involved Fe3+-driven self-assembly of fluorenylmethyloxycarbonyl (Fmoc)-protected amino acids. By adding a zinc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1 (HIF-1) inhibitor acriflavine (ACF) during the Fe3+-promoted self-assembly of Fmoc-protected cysteine (Fmoc-Cys), the nanovesicles Fmoc- Cys/Fe@Pc and Fmoc-Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly. The released Fe3+ could catalyze the transformation of H2O2 enriched in cancer cells to oxygen efficiently, thereby ameliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc-Cys/Fe@Pc/ACF exhibited higher in vitro and in vivo photodynamic activities than Fmoc-Cys/Fe@Pc, demonstrating the synergistic effect of ZnPc and ACF.

Research Area(s)

  • catalase, hypoxia, photodynamic therapy, phthalocyanine, self-assembly

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Publication fingerprints text

100
Catalase Chemistry
100
Pc Chemistry
100
Ion Chemistry
100
Oxygen Chemical Engineering
100
ions INIS
100
catalase INIS
100
tumors INIS
100
acriflavine INIS
100
Ferric Ion Keyphrases
100
Photosensitizing Keyphrases
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Citation Format(s)

[ RIS ] [ BibTeX ]
Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors. / Li, Yongxin; Sun, Pan; Zhao, Luyang et al.
In: Angewandte Chemie, Vol. 132, No. 51, 14.12.2020, p. 23428-23438.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review