FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition

Chenjie Xu; Zhenglong Yuan; Nathan Kohler; Jaemin Kim; Maureen A. Chung; Shouheng Sun

doi:10.1021/ja905938a

FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition

Chenjie Xu, Zhenglong Yuan, Nathan Kohler, Jaemin Kim, Maureen A. Chung, Shouheng Sun^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

184 Citations (Scopus)

Abstract

Chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) show the controlled release of Fe in low pH solution. The released Fe catalyzes H₂O₂ decomposition into reactive oxygen species within cells, causing fast oxidation and deterioration of cellular membranes. Functionalized with luteinizing hormone-releasing hormone (LHRH) peptide via phospholipid, the fcc-FePt NPs can bind preferentially to the human ovarian cancer cell line (A2780) that overexpresses LHRH receptors and exhibit high toxicity to these tumor cells. In contrast, the fcc-FePt NPs pre-etched in the low pH (4.8) buffer solution show nonappreciable cytotoxicity. The work demonstrates that fcc-FePt NPs may function as a new type of agent for controlled cancer therapy. © 2009 American Chemical Society.

Original language	English
Pages (from-to)	15346-15351
Journal	Journal of the American Chemical Society
Volume	131
Issue number	42
Online published	1 Oct 2009
DOIs	https://doi.org/10.1021/ja905938a
Publication status	Published - 28 Oct 2009
Externally published	Yes

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title = "FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition",

abstract = "Chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) show the controlled release of Fe in low pH solution. The released Fe catalyzes H2O2 decomposition into reactive oxygen species within cells, causing fast oxidation and deterioration of cellular membranes. Functionalized with luteinizing hormone-releasing hormone (LHRH) peptide via phospholipid, the fcc-FePt NPs can bind preferentially to the human ovarian cancer cell line (A2780) that overexpresses LHRH receptors and exhibit high toxicity to these tumor cells. In contrast, the fcc-FePt NPs pre-etched in the low pH (4.8) buffer solution show nonappreciable cytotoxicity. The work demonstrates that fcc-FePt NPs may function as a new type of agent for controlled cancer therapy. {\textcopyright} 2009 American Chemical Society.",

author = "Chenjie Xu and Zhenglong Yuan and Nathan Kohler and Jaemin Kim and Chung, {Maureen A.} and Shouheng Sun",

year = "2009",

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T1 - FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition

AU - Xu, Chenjie

AU - Yuan, Zhenglong

AU - Kohler, Nathan

AU - Kim, Jaemin

AU - Chung, Maureen A.

AU - Sun, Shouheng

PY - 2009/10/28

Y1 - 2009/10/28

N2 - Chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) show the controlled release of Fe in low pH solution. The released Fe catalyzes H2O2 decomposition into reactive oxygen species within cells, causing fast oxidation and deterioration of cellular membranes. Functionalized with luteinizing hormone-releasing hormone (LHRH) peptide via phospholipid, the fcc-FePt NPs can bind preferentially to the human ovarian cancer cell line (A2780) that overexpresses LHRH receptors and exhibit high toxicity to these tumor cells. In contrast, the fcc-FePt NPs pre-etched in the low pH (4.8) buffer solution show nonappreciable cytotoxicity. The work demonstrates that fcc-FePt NPs may function as a new type of agent for controlled cancer therapy. © 2009 American Chemical Society.

AB - Chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) show the controlled release of Fe in low pH solution. The released Fe catalyzes H2O2 decomposition into reactive oxygen species within cells, causing fast oxidation and deterioration of cellular membranes. Functionalized with luteinizing hormone-releasing hormone (LHRH) peptide via phospholipid, the fcc-FePt NPs can bind preferentially to the human ovarian cancer cell line (A2780) that overexpresses LHRH receptors and exhibit high toxicity to these tumor cells. In contrast, the fcc-FePt NPs pre-etched in the low pH (4.8) buffer solution show nonappreciable cytotoxicity. The work demonstrates that fcc-FePt NPs may function as a new type of agent for controlled cancer therapy. © 2009 American Chemical Society.

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M3 - RGC 21 - Publication in refereed journal

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EP - 15351

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 42

ER -

FePt Nanoparticles as an Fe Reservoir for Controlled Fe Release and Tumor Inhibition

Abstract

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