Feline Immunodeficiency Virus Integration in B-Cell Lymphoma Identifies a Candidate Tumor Suppressor Gene on Human Chromosome 15q15

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Anne Terry
  • Julie MacDonald
  • Elizabeth Gault
  • Stan Cevario
  • Stephen J. O'Brien
  • Ewan Cameron
  • James C. Neil

Detail(s)

Original languageEnglish
Pages (from-to)7175-7180
Journal / PublicationCancer Research
Volume62
Issue number24
Online published15 Dec 2002
Publication statusPublished - Dec 2002
Externally publishedYes

Abstract

Infection with immunosuppressive lentiviruses is associated with increased cancer risk, but most studies have implicated indirect mechanisms as the tumor cells generally lack integrated viral sequences. An exception was found in a B-cell lymphoma (Q254) where the tumor cells contained a single integrated feline immunodeficiency virus genome. Additional analysis now indicates that feline immunodeficiency virus integration in lymphoma Q254 resulted in promoter insertion and truncation of a conserved gene on feline chromosome B3, whereas the unaffected allele of the gene appeared to be transcriptionally down-regulated. The orthologous human gene (FLJ12973), is expressed ubiquitously and encodes a WD-repeat protein with structural similarity to DDB2, the small subunit of the xeroderma pigmentosum XP-E complex. Moreover, the gene is located within a region of frequent tumor-specific deletions on chromosome 15q15. These observations demonstrate the direct mutagenic potential of the lentiviruses and identify a new candidate tumor suppressor gene.

Citation Format(s)

Feline Immunodeficiency Virus Integration in B-Cell Lymphoma Identifies a Candidate Tumor Suppressor Gene on Human Chromosome 15q15. / Beatty, Julia; Terry, Anne; MacDonald, Julie; Gault, Elizabeth; Cevario, Stan; O'Brien, Stephen J.; Cameron, Ewan; Neil, James C.

In: Cancer Research, Vol. 62, No. 24, 12.2002, p. 7175-7180.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review