Feline Immunodeficiency Virus: Current Knowledge and Future Directions

Paweł M. Bęczkowski; Julia A. Beatty

doi:10.1016/j.yasa.2022.05.007

Feline Immunodeficiency Virus: Current Knowledge and Future Directions

Paweł M. Bęczkowski^*, Julia A. Beatty

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

240 Downloads (CityUHK Scholars)

Abstract

• Clinical outcomes in FIV-infected cats are variable and poorly defined. The immunodeficiency that accompanies infection can, and often does, remain subclinical.

• FIV infection is lifelong. Serology is the first-line diagnostic test to identify infected cats. PCR is available for confirmation if required.

• Viral, host, and environmental factors that influence prognosis in individual FIV-infected cats are unclear. Reliable surrogate markers to predict clinical progression are not available.

• Key to the management of FIV-infected cats is preventive health care and early detection and investigation of clinical problems.

• A commercial FIV vaccine is available in only a few regions including Australia, New Zealand, and Japan. Interference with diagnostic testing by the commercial FIV vaccine is largely resolved, but vaccine efficacy in the field remains questionable. FIV vaccination is classified as noncore by WSAVA Vaccination Guidelines Group.

Original language	English
Pages (from-to)	145-159
Number of pages	15
Journal	Advances in Small Animal Care
Volume	3
Issue number	1
Online published	31 Oct 2022
DOIs	https://doi.org/10.1016/j.yasa.2022.05.007
Publication status	Published - Nov 2022

Research Keywords

Retrovirus
Lentivirus
Immunodeficiency
Viral diversity
Receptor usage
CD134
CXCR4
Vaccine

Publisher's Copyright Statement

This full text is made available under CC-BY-NC-ND 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/

Access Output

10.1016/j.yasa.2022.05.007

120507987.pdfFinal Published version, 970 KBLicence: CC BY-NC-ND

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{8e1ef92a7aff44f696105bbfdf8be33d,

title = "Feline Immunodeficiency Virus: Current Knowledge and Future Directions",

abstract = "• Clinical outcomes in FIV-infected cats are variable and poorly defined. The immunodeficiency that accompanies infection can, and often does, remain subclinical.• FIV infection is lifelong. Serology is the first-line diagnostic test to identify infected cats. PCR is available for confirmation if required.• Viral, host, and environmental factors that influence prognosis in individual FIV-infected cats are unclear. Reliable surrogate markers to predict clinical progression are not available.• Key to the management of FIV-infected cats is preventive health care and early detection and investigation of clinical problems.• A commercial FIV vaccine is available in only a few regions including Australia, New Zealand, and Japan. Interference with diagnostic testing by the commercial FIV vaccine is largely resolved, but vaccine efficacy in the field remains questionable. FIV vaccination is classified as noncore by WSAVA Vaccination Guidelines Group.",

keywords = "Retrovirus, Lentivirus, Immunodeficiency, Viral diversity, Receptor usage, CD134, CXCR4, Vaccine",

author = "B{\c e}czkowski, {Pawe{\l} M.} and Beatty, {Julia A.}",

year = "2022",

month = nov,

doi = "10.1016/j.yasa.2022.05.007",

language = "English",

volume = "3",

pages = "145--159",

journal = "Advances in Small Animal Care",

issn = "2666-450X",

publisher = "Elsevier B.V.",

number = "1",

}

TY - JOUR

T1 - Feline Immunodeficiency Virus

T2 - Current Knowledge and Future Directions

AU - Bęczkowski, Paweł M.

AU - Beatty, Julia A.

PY - 2022/11

Y1 - 2022/11

N2 - • Clinical outcomes in FIV-infected cats are variable and poorly defined. The immunodeficiency that accompanies infection can, and often does, remain subclinical.• FIV infection is lifelong. Serology is the first-line diagnostic test to identify infected cats. PCR is available for confirmation if required.• Viral, host, and environmental factors that influence prognosis in individual FIV-infected cats are unclear. Reliable surrogate markers to predict clinical progression are not available.• Key to the management of FIV-infected cats is preventive health care and early detection and investigation of clinical problems.• A commercial FIV vaccine is available in only a few regions including Australia, New Zealand, and Japan. Interference with diagnostic testing by the commercial FIV vaccine is largely resolved, but vaccine efficacy in the field remains questionable. FIV vaccination is classified as noncore by WSAVA Vaccination Guidelines Group.

AB - • Clinical outcomes in FIV-infected cats are variable and poorly defined. The immunodeficiency that accompanies infection can, and often does, remain subclinical.• FIV infection is lifelong. Serology is the first-line diagnostic test to identify infected cats. PCR is available for confirmation if required.• Viral, host, and environmental factors that influence prognosis in individual FIV-infected cats are unclear. Reliable surrogate markers to predict clinical progression are not available.• Key to the management of FIV-infected cats is preventive health care and early detection and investigation of clinical problems.• A commercial FIV vaccine is available in only a few regions including Australia, New Zealand, and Japan. Interference with diagnostic testing by the commercial FIV vaccine is largely resolved, but vaccine efficacy in the field remains questionable. FIV vaccination is classified as noncore by WSAVA Vaccination Guidelines Group.

KW - Retrovirus

KW - Lentivirus

KW - Immunodeficiency

KW - Viral diversity

KW - Receptor usage

KW - CD134

KW - CXCR4

KW - Vaccine

U2 - 10.1016/j.yasa.2022.05.007

DO - 10.1016/j.yasa.2022.05.007

M3 - RGC 21 - Publication in refereed journal

SN - 2666-450X

VL - 3

SP - 145

EP - 159

JO - Advances in Small Animal Care

JF - Advances in Small Animal Care

IS - 1

ER -

Feline Immunodeficiency Virus: Current Knowledge and Future Directions

Abstract

Research Keywords

Publisher's Copyright Statement

Access Output

Other Access Options

Permanent Link

Fingerprint

Cite this