Fatigue as the missing link between bone fragility and fracture

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

29 Scopus Citations
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Author(s)

  • Claire Acevedo
  • Vincent A. Stadelmann
  • Dominique P. Pioletti
  • Tamara Alliston
  • Robert O. Ritchie

Detail(s)

Original languageEnglish
Pages (from-to)62-71
Journal / PublicationNature Biomedical Engineering
Volume2
Issue number2
Online published22 Jan 2018
Publication statusPublished - Feb 2018
Externally publishedYes

Abstract

The prevention of fragility fractures in bone-pathologic fractures resulting from daily activity and mostly occurring in the elderly population-has been a long-Term clinical quest. Recent research indicating that falls in the elderly might be the consequence of fracture rather than its cause has raised fundamental questions about the origin of fragility fractures. Is day-To-day cyclic loading, instead of a single-load event such as a fall, the main cause of progressively growing fractures? Are fragility fractures predominantly affected by bone quality rather than bone mass, which is the clinical indicator of fracture risk? Do osteocytes actively participate in the bone repair process? In this Perspective, we discuss the central role of cyclic fatigue in bone fragility fracture.

Citation Format(s)

Fatigue as the missing link between bone fragility and fracture. / Acevedo, Claire; Stadelmann, Vincent A.; Pioletti, Dominique P.; Alliston, Tamara; Ritchie, Robert O.

In: Nature Biomedical Engineering, Vol. 2, No. 2, 02.2018, p. 62-71.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review