Fast-scanning photoacoustic microscopy with a side-looking fiber optic ultrasound sensor

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

14 Scopus Citations
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Author(s)

  • Yizhi LIANG
  • Jin-Wei LIU
  • Long JIN
  • Bai-Ou GUAN
  • Lidai WANG

Detail(s)

Original languageEnglish
Article number#336107
Pages (from-to)5809-5816
Journal / PublicationBiomedical Optics Express
Volume9
Issue number11
Online published29 Oct 2018
Publication statusPublished - 1 Nov 2018

Link(s)

Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) images biological tissue with sub-cellular resolution and optical absorption contrast. OR-PAM is limited by the tradeoff among imaging speed, field of view, and sensitivity. In this work, we present an OR-PAM technique based on an unfocused side-looking fiber optic ultrasound (FOUS) sensor, which achieves high imaging speed, large field of view, and good sensitivity for in vivo imaging. The FOUS sensor is developed based on a dual-polarized fiber laser and read out with real-time frequency demodulation. Via minimizing the readout noise, the sensor offers a noise-equivalent pressure of 43.6 Pa, enabling high detection sensitivity over a large field of view. High imaging speed is achieved via scanning the laser beam with a 2D galvo mirror in the ultrasound detection area. Microvascular imaging with a frame rate of 2 Hz over a 2 × 2 mm2 area has been demonstrated in the mouse ear. The new OR-PAM technique may be used in the visualization of biological and physiologic dynamics.

Research Area(s)

  • MOUSE-BRAIN, SPEED, SENSITIVITY

Citation Format(s)

Fast-scanning photoacoustic microscopy with a side-looking fiber optic ultrasound sensor. / LIANG, Yizhi; LIU, Jin-Wei; JIN, Long; GUAN, Bai-Ou; WANG, Lidai.

In: Biomedical Optics Express, Vol. 9, No. 11, #336107, 01.11.2018, p. 5809-5816.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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