@inproceedings{61b6e73d5d5b439d8f391fab4a923b5e,
title = "Fast synthesis of [11C]raclopride, a positron emission tomography radiotracer, on a microfluidic chip",
abstract = "[11C]Raclopride ([11C]Rac) is a radiotracer compound used in positron emission tomography (PET) to study the dopamine receptor concentration in vivo. Synthesis process of the compound currently takes between 25-50 minutes, resulting in a substantial decay of the C-11 radionuclide, since it has a half-life of 20.4 min. In this investigation we study the radiolabeling process of desmethyl raclopride (DMR), the precursor compound to make this radiotracer on a microfluidic chip. Initially the un-labeled synthesis ({"}cold{"} synthesis) process was optimized on the microfluidic chip. Then the optimal conditions were used to synthesize the radiolabeled compound ({"}hot{"} synthesis). Using this microfluidic device we were able to reduce the reaction time to 1/5th and the amount of the precursor compound to 1/10th of that of the conventional synthesis. The yields for the cold synthesis were higher than those for the hot synthesis, and hence the reaction kinetics and stiochiometry need to be considered dered in order to optimize the hot synthesis process. {\textcopyright} 2009 CBMS.",
keywords = "C-11, Methylation, Micromixer, PET, Radioactive synthesis, C-11, Methylation, Micromixer, PET, Radioactive synthesis, C-11, Methylation, Micromixer, PET, Radioactive synthesis",
author = "Samar Haroun and Salma Jivan and Li, \{Paul C.H.\} and Ruth, \{Thomas J.\}",
note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to
[email protected].; 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 ; Conference date: 01-11-2009 Through 05-11-2009",
year = "2009",
language = "English",
isbn = "9780979806421",
series = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "1288--1290",
booktitle = "Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}