Fast DNA hybridization on a multi-sample multi-probe microfluidic microarray compact disc

X. Y. Peng, Paul C. H. Li, H. Z. Yu, M. Parameswaran, S. Beardmore, W. L. Chou

Research output: Chapters, Conference Papers, Creative and Literary WorksRGC 32 - Refereed conference paper (with host publication)peer-review

Abstract

A microfluidic method has been developed to generate a DNA microarray on a compact disk. Probe immobilization and DNA hybridization are both achieved within microchannels on a microfluidic microarray assembly (MMA). One femtomole of oligonucleotide samples could be detected in 3 min. The reaction times in both processes are much shorter than in conventional methods. It is because the high surface-to-volume ratio achievable in the microchannels facilitates fast surface reaction rates.
Original languageEnglish
Title of host publication2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings
Pages332-335
Publication statusPublished - 2005
Externally publishedYes
Event2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 - Anaheim, CA, United States
Duration: 8 May 200512 May 2005

Publication series

Name2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005 Technical Proceedings

Conference

Conference2005 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2005
PlaceUnited States
CityAnaheim, CA
Period8/05/0512/05/05

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

  • Centrifugal flow
  • DNA hybridization
  • Microarray
  • Microfluidic chip
  • Pathogen detection

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