Facilitating PET Imaging: Eco-Friendly Purification Using Solid-Phase Material for Labeling Metal-Based Radiopharmaceuticals

Yik-Hoi Yeung; Leilei Zhang; Hei-Yui Kai; Pak-Lun Lam; Tao Zhang; Yue Wu; Ga-Lai Law; Chen Xie; Ka-Leung Wong

doi:10.1021/jacsau.5c00394

Facilitating PET Imaging: Eco-Friendly Purification Using Solid-Phase Material for Labeling Metal-Based Radiopharmaceuticals

Yik-Hoi Yeung
, Leilei Zhang
, Hei-Yui Kai
, Pak-Lun Lam
, Tao Zhang^*
, Yue Wu^*
, Ga-Lai Law^*
, Chen Xie^*
, Ka-Leung Wong^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

1 Citation (Scopus)

Abstract

Radiopharmaceuticals rely on radioactive isotopes for diagnosis and therapy, particularly in positron emission tomography (PET), but removing excess radiometals to ensure biosafety and imaging quality is a time-consuming process that causes radiotracer decay, while organic eluents might cause health hazards. In this study, we present a solid-phase material, NOTA-resin, which enables efficient radiometal removal (clearance rate >97% in 4 min) in a single step, at room temperature, and without organic solvents. Furthermore, we have validated the practicability of NOTA-resin in tumor-bearing mice models, demonstrating its compatibility with commercial radiotracers without adverse effects on tumor targeting and PET imaging quality while significantly shortening processing times, saving resources, and reducing waste. © 2025 The Authors. Published by American Chemical Society.

Original language	English
Pages (from-to)	3213-3218
Number of pages	6
Journal	JACS Au
Volume	5
Issue number	7
Online published	20 Jun 2025
DOIs	https://doi.org/10.1021/jacsau.5c00394
Publication status	Published - 28 Jul 2025
Externally published	Yes

Funding

K.-L.W. gratefully acknowledges the financial assistance from the Hong Kong Research Grants Council Grant No. 12300021, NSFC/RGC Joint Research Scheme (N_PolyU209/21), the Centre for Medical Engineering of Molecular and Biological Probes (AoE/M-401/20), and the Innovation and Technology Fund − Partnership Research Programme (PRP/040/23FX). The precious advice in writing provided by Dr. Wai-Sum Lo from the Department of Applied Biology and Chemical Technology (ABCT) of The Hong Kong Polytechnic University (HKPolyU) is greatly appreciated. We also appreciate the service of high-resolution mass spectrometry provided by The University Research Facility in Life Sciences (ULS) of HKPolyU.

Research Keywords

green chemistry
positron emission tomography
postradiolabeling purification
radiopharmaceuticals
solid phase extraction

Publisher's Copyright Statement

This full text is made available under CC-BY-NC-ND 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/

RGC Funding Information

RGC-funded

Access Output

10.1021/jacsau.5c00394

422763828.pdfFinal Published version, 3.74 MBLicence: CC BY-NC-ND

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{1ff7185c835044a6b7fc4917db099ea4,

title = "Facilitating PET Imaging: Eco-Friendly Purification Using Solid-Phase Material for Labeling Metal-Based Radiopharmaceuticals",

abstract = "Radiopharmaceuticals rely on radioactive isotopes for diagnosis and therapy, particularly in positron emission tomography (PET), but removing excess radiometals to ensure biosafety and imaging quality is a time-consuming process that causes radiotracer decay, while organic eluents might cause health hazards. In this study, we present a solid-phase material, NOTA-resin, which enables efficient radiometal removal (clearance rate >97\% in 4 min) in a single step, at room temperature, and without organic solvents. Furthermore, we have validated the practicability of NOTA-resin in tumor-bearing mice models, demonstrating its compatibility with commercial radiotracers without adverse effects on tumor targeting and PET imaging quality while significantly shortening processing times, saving resources, and reducing waste. {\textcopyright} 2025 The Authors. Published by American Chemical Society.",

keywords = "green chemistry, positron emission tomography, postradiolabeling purification, radiopharmaceuticals, solid phase extraction",

author = "Yik-Hoi Yeung and Leilei Zhang and Hei-Yui Kai and Pak-Lun Lam and Tao Zhang and Yue Wu and Ga-Lai Law and Chen Xie and Ka-Leung Wong",

year = "2025",

month = jul,

day = "28",

doi = "10.1021/jacsau.5c00394",

language = "English",

volume = "5",

pages = "3213--3218",

number = "7",

}

TY - JOUR

T1 - Facilitating PET Imaging

T2 - Eco-Friendly Purification Using Solid-Phase Material for Labeling Metal-Based Radiopharmaceuticals

AU - Yeung, Yik-Hoi

AU - Zhang, Leilei

AU - Kai, Hei-Yui

AU - Lam, Pak-Lun

AU - Zhang, Tao

AU - Wu, Yue

AU - Law, Ga-Lai

AU - Xie, Chen

AU - Wong, Ka-Leung

PY - 2025/7/28

Y1 - 2025/7/28

N2 - Radiopharmaceuticals rely on radioactive isotopes for diagnosis and therapy, particularly in positron emission tomography (PET), but removing excess radiometals to ensure biosafety and imaging quality is a time-consuming process that causes radiotracer decay, while organic eluents might cause health hazards. In this study, we present a solid-phase material, NOTA-resin, which enables efficient radiometal removal (clearance rate >97% in 4 min) in a single step, at room temperature, and without organic solvents. Furthermore, we have validated the practicability of NOTA-resin in tumor-bearing mice models, demonstrating its compatibility with commercial radiotracers without adverse effects on tumor targeting and PET imaging quality while significantly shortening processing times, saving resources, and reducing waste. © 2025 The Authors. Published by American Chemical Society.

AB - Radiopharmaceuticals rely on radioactive isotopes for diagnosis and therapy, particularly in positron emission tomography (PET), but removing excess radiometals to ensure biosafety and imaging quality is a time-consuming process that causes radiotracer decay, while organic eluents might cause health hazards. In this study, we present a solid-phase material, NOTA-resin, which enables efficient radiometal removal (clearance rate >97% in 4 min) in a single step, at room temperature, and without organic solvents. Furthermore, we have validated the practicability of NOTA-resin in tumor-bearing mice models, demonstrating its compatibility with commercial radiotracers without adverse effects on tumor targeting and PET imaging quality while significantly shortening processing times, saving resources, and reducing waste. © 2025 The Authors. Published by American Chemical Society.

KW - green chemistry

KW - positron emission tomography

KW - postradiolabeling purification

KW - radiopharmaceuticals

KW - solid phase extraction

UR - https://www.scopus.com/pages/publications/105008812660

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-105008812660&origin=recordpage

U2 - 10.1021/jacsau.5c00394

DO - 10.1021/jacsau.5c00394

M3 - RGC 21 - Publication in refereed journal

SN - 2691-3704

VL - 5

SP - 3213

EP - 3218

JO - JACS Au

JF - JACS Au

IS - 7

ER -

Facilitating PET Imaging: Eco-Friendly Purification Using Solid-Phase Material for Labeling Metal-Based Radiopharmaceuticals

Abstract

Funding

Research Keywords

Publisher's Copyright Statement

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Cite this