Facile synthesis of highly emissive carbon dots from pyrolysis of glycerol; gram scale production of carbon dots/mSiO2 for cell imaging and drug release

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)14403-14409
Journal / PublicationJournal of Materials Chemistry
Volume22
Issue number29
Online published24 May 2012
Publication statusPublished - 7 Aug 2012
Externally publishedYes

Abstract

We report on a facile method to synthesize carbon dots (CDs) using glycerol solvent as a single precursor via a pyrolysis process free from catalysts. This method is extremely simple and economical, and provides a feasible route for mass production of highly emissive CDs. For rationalization, a mechanism incorporating dehydration of glycerol, followed by acrylaldehyde formation is tentatively proposed for CD production. Further systematic improvement of particle homogeneity is made by harnessing the growth of CDs inside the mesoporous silica nanoparticles that act as a nano-reactor to regulate the size distribution. Simultaneously capping a polyethylene glycol (PEG)-derived reactant onto the CDs@SiO 2 enhances their luminescence, stability and bio-compatibility. The as-prepared CDs@mSiO 2-PEG nanocomposites are then loaded with the anti-cancer drug doxorubicin (DOX), so that the controlled release of DOX could be monitored by both time-dependent and spatially resolved ratiometric fluorescence intensity for CDs versus DOX in HeLa cells, successfully demonstrating that the CDs@mSiO 2-PEG nanocomposites are suitable for cell imaging and drug release.  

Citation Format(s)

Facile synthesis of highly emissive carbon dots from pyrolysis of glycerol; gram scale production of carbon dots/mSiO2 for cell imaging and drug release. / Lai, Chih-Wei; Hsiao, Yi-Hsuan; Peng, Yung-Kang; Chou, Pi-Tai.

In: Journal of Materials Chemistry, Vol. 22, No. 29, 07.08.2012, p. 14403-14409.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review