Facile Preparation of Phthalocyanine-Based Nanodots for Photoacoustic Imaging and Photothermal Cancer Therapy in Vivo

Fengshou Wu; Liangliang Yue; Kai Cheng; Jun Chen; Ka-Leung Wong; Wai-Kwok Wong; Xunjin Zhu

doi:10.1021/acsbiomaterials.0c00684

Facile Preparation of Phthalocyanine-Based Nanodots for Photoacoustic Imaging and Photothermal Cancer Therapy in Vivo

Fengshou Wu^*, Liangliang Yue, Kai Cheng, Jun Chen^*, Ka-Leung Wong, Wai-Kwok Wong, Xunjin Zhu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

37 Citations (Scopus)

Abstract

The development of near-infrared (NIR)-absorbing nanoagents for personalized multifunctional phototheranostics has attracted considerable attention in the past decade. Recently, the organic nanomaterials with good biosafety are considered as promising phototheranostic agents, while their facile synthesis remains challenging. Inspired by the preparation of carbon nanodots, we fabricate the NIR-absorbing phthalocyanine-based nanodots (ZnPc-NDs) using a facile method for multifunctional phototheranostics. The significant aggregation of phthalocyanines in nanodots induces a complete fluorescence quenching, which affords a high photothermal conversion efficiency (η = 45.7%). The ZnPc-NDs disperse very well in water media with an average diameter around 80 nm. Further conjugation of biotin on the surface of ZnPc-NDs affords tumor-targeting phthalocyanine nanodots (ZnPc-BT). The ZnPc-BT are demonstrated with favorable biocompatibility, intense photoacoustic signals, high tumor accumulation, and effective tumor suppression in vivo. This Article provides a new insight for further developing nanomedicines with imaging and therapeutic functions to treat cancers precisely and effectively. Copyright © 2020 American Chemical Society.

Original language	English
Pages (from-to)	5230-5239
Journal	ACS Biomaterials Science and Engineering
Volume	6
Issue number	9
Online published	25 Aug 2020
DOIs	https://doi.org/10.1021/acsbiomaterials.0c00684
Publication status	Published - 14 Sept 2020
Externally published	Yes

Funding

This work was supported by the National Natural Science Foundation of China (NSFC) (grant no. 21601142) and the Natural Science Foundation of Hubei Province (grant no. 2018CFB159). X.Z. is thankful for the financial support from the Innovation and Technology Commission (UIM/373) and the Interinstitutional Collaborative Research Scheme (RC-ICRS-18-19-01A), and from the Interdisciplinary Research Matching Scheme (RC-IRMS/16/17/02CHEM).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

nanodots
organic nanoparticles
photoacoustic imaging
photothermal therapy
phthalocyanine

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10.1021/acsbiomaterials.0c00684

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title = "Facile Preparation of Phthalocyanine-Based Nanodots for Photoacoustic Imaging and Photothermal Cancer Therapy in Vivo",

abstract = "The development of near-infrared (NIR)-absorbing nanoagents for personalized multifunctional phototheranostics has attracted considerable attention in the past decade. Recently, the organic nanomaterials with good biosafety are considered as promising phototheranostic agents, while their facile synthesis remains challenging. Inspired by the preparation of carbon nanodots, we fabricate the NIR-absorbing phthalocyanine-based nanodots (ZnPc-NDs) using a facile method for multifunctional phototheranostics. The significant aggregation of phthalocyanines in nanodots induces a complete fluorescence quenching, which affords a high photothermal conversion efficiency (η = 45.7%). The ZnPc-NDs disperse very well in water media with an average diameter around 80 nm. Further conjugation of biotin on the surface of ZnPc-NDs affords tumor-targeting phthalocyanine nanodots (ZnPc-BT). The ZnPc-BT are demonstrated with favorable biocompatibility, intense photoacoustic signals, high tumor accumulation, and effective tumor suppression in vivo. This Article provides a new insight for further developing nanomedicines with imaging and therapeutic functions to treat cancers precisely and effectively. Copyright {\textcopyright} 2020 American Chemical Society.",

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author = "Fengshou Wu and Liangliang Yue and Kai Cheng and Jun Chen and Ka-Leung Wong and Wai-Kwok Wong and Xunjin Zhu",

year = "2020",

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TY - JOUR

T1 - Facile Preparation of Phthalocyanine-Based Nanodots for Photoacoustic Imaging and Photothermal Cancer Therapy in Vivo

AU - Wu, Fengshou

AU - Yue, Liangliang

AU - Cheng, Kai

AU - Chen, Jun

AU - Wong, Ka-Leung

AU - Wong, Wai-Kwok

AU - Zhu, Xunjin

PY - 2020/9/14

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N2 - The development of near-infrared (NIR)-absorbing nanoagents for personalized multifunctional phototheranostics has attracted considerable attention in the past decade. Recently, the organic nanomaterials with good biosafety are considered as promising phototheranostic agents, while their facile synthesis remains challenging. Inspired by the preparation of carbon nanodots, we fabricate the NIR-absorbing phthalocyanine-based nanodots (ZnPc-NDs) using a facile method for multifunctional phototheranostics. The significant aggregation of phthalocyanines in nanodots induces a complete fluorescence quenching, which affords a high photothermal conversion efficiency (η = 45.7%). The ZnPc-NDs disperse very well in water media with an average diameter around 80 nm. Further conjugation of biotin on the surface of ZnPc-NDs affords tumor-targeting phthalocyanine nanodots (ZnPc-BT). The ZnPc-BT are demonstrated with favorable biocompatibility, intense photoacoustic signals, high tumor accumulation, and effective tumor suppression in vivo. This Article provides a new insight for further developing nanomedicines with imaging and therapeutic functions to treat cancers precisely and effectively. Copyright © 2020 American Chemical Society.

AB - The development of near-infrared (NIR)-absorbing nanoagents for personalized multifunctional phototheranostics has attracted considerable attention in the past decade. Recently, the organic nanomaterials with good biosafety are considered as promising phototheranostic agents, while their facile synthesis remains challenging. Inspired by the preparation of carbon nanodots, we fabricate the NIR-absorbing phthalocyanine-based nanodots (ZnPc-NDs) using a facile method for multifunctional phototheranostics. The significant aggregation of phthalocyanines in nanodots induces a complete fluorescence quenching, which affords a high photothermal conversion efficiency (η = 45.7%). The ZnPc-NDs disperse very well in water media with an average diameter around 80 nm. Further conjugation of biotin on the surface of ZnPc-NDs affords tumor-targeting phthalocyanine nanodots (ZnPc-BT). The ZnPc-BT are demonstrated with favorable biocompatibility, intense photoacoustic signals, high tumor accumulation, and effective tumor suppression in vivo. This Article provides a new insight for further developing nanomedicines with imaging and therapeutic functions to treat cancers precisely and effectively. Copyright © 2020 American Chemical Society.

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Facile Preparation of Phthalocyanine-Based Nanodots for Photoacoustic Imaging and Photothermal Cancer Therapy in Vivo

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