Facile functionalization and phase reduction route of magnetic iron oxide nanoparticles for conjugation of matrix metalloproteinase

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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  • Dan Li
  • Diana Djunaedi
  • Jolen Justin Gooding
  • Cordelia Selomulya
  • Rose Amal


Original languageEnglish
Journal / PublicationAdvanced Engineering Materials
Issue number6
Publication statusPublished - Jun 2010
Externally publishedYes


A protocol for the simultaneous functionalization and phase reduction route of iron oxide magnetic nanoparticles (MNPs) and its further bioconjugation is presented. It was found that surface functionalization of maghemite (γ-Fe2O3) nanoparticles with mercaptopropyltrimethoxysilane (MPTMS) under anoxic environment at above 80 °C promotes in situ conversion to magnetite (Fe3O4). Full conversion to Fe3O4, as probed by Mössbauer spectroscopy, with accompanied increase in the composite saturation magnetization, was achieved at 120 °C. By controlling the MPTMS concentration, the resultant silane-MNPs morphology can be tuned from having homogeneous thin layer (2-weighted MRI contrast can be achieved simultaneously. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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