Fabrication of micropillar substrates using replicas of alpha-particle irradiated and chemically etched PADC films

C. K M Ng; E. Y W Chong; V. A L Roy; K. M C Cheung; K. W K Yeung; K. N. Yu

doi:10.1016/j.apradiso.2011.11.019

Fabrication of micropillar substrates using replicas of alpha-particle irradiated and chemically etched PADC films

C. K M Ng, E. Y W Chong, V. A L Roy, K. M C Cheung, K. W K Yeung, K. N. Yu

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Abstract

We proposed a simple method to fabricate micropillar substrates. Polyallyldiglycol carbonate (PADC) films were irradiated by alpha particles and then chemically etched to form a cast with micron-scale spherical pores. A polydimethylsiloxane (PDMS) replica of this PADC film gave a micropillar substrate with micron-scale spherical pillars. HeLa cells cultured on such a micropillar substrate had significantly larger percentage of cells entering S-phase, attached cell numbers and cell spreading areas. © 2011 Elsevier Ltd.

Original language	English
Pages (from-to)	1432-1435
Journal	Applied Radiation and Isotopes
Volume	70
Issue number	7
DOIs	https://doi.org/10.1016/j.apradiso.2011.11.019
Publication status	Published - Jul 2012

Research Keywords

Alpha particle
Cell proliferation
HeLa cells
Micropillar substrate
PADC
PDMS

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title = "Fabrication of micropillar substrates using replicas of alpha-particle irradiated and chemically etched PADC films",

abstract = "We proposed a simple method to fabricate micropillar substrates. Polyallyldiglycol carbonate (PADC) films were irradiated by alpha particles and then chemically etched to form a cast with micron-scale spherical pores. A polydimethylsiloxane (PDMS) replica of this PADC film gave a micropillar substrate with micron-scale spherical pillars. HeLa cells cultured on such a micropillar substrate had significantly larger percentage of cells entering S-phase, attached cell numbers and cell spreading areas. {\textcopyright} 2011 Elsevier Ltd.",

keywords = "Alpha particle, Cell proliferation, HeLa cells, Micropillar substrate, PADC, PDMS",

author = "Ng, {C. K M} and Chong, {E. Y W} and Roy, {V. A L} and Cheung, {K. M C} and Yeung, {K. W K} and Yu, {K. N.}",

year = "2012",

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language = "English",

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journal = "Applied Radiation and Isotopes",

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TY - JOUR

T1 - Fabrication of micropillar substrates using replicas of alpha-particle irradiated and chemically etched PADC films

AU - Ng, C. K M

AU - Chong, E. Y W

AU - Roy, V. A L

AU - Cheung, K. M C

AU - Yeung, K. W K

AU - Yu, K. N.

PY - 2012/7

Y1 - 2012/7

N2 - We proposed a simple method to fabricate micropillar substrates. Polyallyldiglycol carbonate (PADC) films were irradiated by alpha particles and then chemically etched to form a cast with micron-scale spherical pores. A polydimethylsiloxane (PDMS) replica of this PADC film gave a micropillar substrate with micron-scale spherical pillars. HeLa cells cultured on such a micropillar substrate had significantly larger percentage of cells entering S-phase, attached cell numbers and cell spreading areas. © 2011 Elsevier Ltd.

AB - We proposed a simple method to fabricate micropillar substrates. Polyallyldiglycol carbonate (PADC) films were irradiated by alpha particles and then chemically etched to form a cast with micron-scale spherical pores. A polydimethylsiloxane (PDMS) replica of this PADC film gave a micropillar substrate with micron-scale spherical pillars. HeLa cells cultured on such a micropillar substrate had significantly larger percentage of cells entering S-phase, attached cell numbers and cell spreading areas. © 2011 Elsevier Ltd.

KW - Alpha particle

KW - Cell proliferation

KW - HeLa cells

KW - Micropillar substrate

KW - PADC

KW - PDMS

UR - http://www.scopus.com/inward/record.url?scp=84862155947&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84862155947&origin=recordpage

U2 - 10.1016/j.apradiso.2011.11.019

DO - 10.1016/j.apradiso.2011.11.019

M3 - RGC 21 - Publication in refereed journal

SN - 0969-8043

VL - 70

SP - 1432

EP - 1435

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 7

ER -

Fabrication of micropillar substrates using replicas of alpha-particle irradiated and chemically etched PADC films

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Research Keywords

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