Fabrication and testing of hydrogel-based microvalves for flow control in flexible lab-on-a-chip systems

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review

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Author(s)

Detail(s)

Original languageEnglish
Title of host publicationMicrofluidics, BioMEMS, and Medical Microsystems X
Volume8251
Publication statusPublished - 2012
Externally publishedYes

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume8251
ISSN (Print)0277-786X

Conference

TitleMicrofluidics, BioMEMS, and Medical Microsystems X
PlaceUnited States
CitySan Francisco, CA
Period23 - 24 January 2012

Abstract

Due to the ease of fabrication and localized response to stimulus (pH, ionic strength, or heat), many researchers have employed stimuli-responsive hydrogels such as poly(N-isopropylacrylamide) (PNIPAAm) as excellent biocompatible materials for microfluidic actuators. We have previously presented the design and fabrication of a mechanically flexible diaphragm-based actuator by employing a reservoir of thermally responsive hydrogel PNIPAAm and a conductive nanocomposite polymer (C-NCP) heater element. We now present the construction, characterization, and simulation of a hydrogel-based microvalve and its application for flow control with a new inexpensive and efficient flexible heater. In this work, we have fabricated the microvalve using traditional microfabrication and soft lithography processes. We accurately pattern and insert the hydrogel plug structure as a fluidic control component within a microfluidic channel. We demonstrate that swelling and shrinking of the hydrogel plug in the microchannel results in closing and opening of the valve. New simulations of the hydrogel plug design were employed using COMSOL® Multiphysics to show the pressure distribution and hydrogel plug movement as well as fluidic velocity in the simulated channel. We then compare the theoretical computed value with the prediction of the COMSOL simulation result which verifies the functionality of our hydrogel plug microvalve design. © 2012 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Fabrication and testing of hydrogel-based microvalves for flow control in flexible lab-on-a-chip systems. / Li, Ang; Lee, Jonathan; Gray, Bonnie L.; Li, Paul C. H.

Microfluidics, BioMEMS, and Medical Microsystems X. Vol. 8251 2012. 82510Z (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 8251).

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)32_Refereed conference paper (with ISBN/ISSN)peer-review