Extracting gene regulation information for cancer classification

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Pages (from-to)3379-3392
Journal / PublicationPattern Recognition
Volume40
Issue number12
Publication statusPublished - Dec 2007

Abstract

In this paper, we address the problem of extracting gene regulation information from microarray data for cancer classification. From the biological viewpoint, a model of gene regulation probability is established where three types of gene regulation states in a tissue sample are assumed and then two regulation events correlated with the class distinction are defined. Different from the previous approaches, the proposed algorithm uses gene regulation probabilities as carriers of regulation information to select genes and construct classifiers. The proposed approach is successfully applied to two public available microarray data sets, the leukemia data and the prostate data. Experimental results suggest that gene selection based on regulation information can greatly improve cancer classification, and the classifier based on regulation information is more efficient and more stable than several previous classification algorithms. © 2007 Pattern Recognition Society.

Research Area(s)

  • Cancer classification, Gene expression levels, Gene regulation, Microarray, Prediction strength

Citation Format(s)

Extracting gene regulation information for cancer classification. / Wang, Hong-Qiang; Wong, Hau-San; Huang, De-Shuang et al.

In: Pattern Recognition, Vol. 40, No. 12, 12.2007, p. 3379-3392.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review