Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Paulisally Hau Yi Lo
  • Alfred Chi Chung Leung
  • Simon Law
  • Fuh-Mei Duh
  • Michael I Lerman
  • Eric J Stanbridge
  • Maria Li Lung

Detail(s)

Original languageEnglish
Pages (from-to)184-92
Number of pages9
Journal / PublicationCancer Letters
Volume234
Issue number2
Publication statusPublished - 28 Mar 2006
Externally publishedYes

Abstract

The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated. Reduced expression of BLU was detected in some ESCC cell lines and tumor tissues and the difference was quantitated by real-time quantitative polymerase chain reaction. Methylation specific-PCR revealed the down-regulation of BLU by epigenetic inactivation. However, exogenous expression of BLU did not functionally suppress tumorigenicity in nude mice. These results suggest that over-expression of BLU alone is not sufficient to inhibit tumorigenicity. Further studies on BLU interacting proteins are required to elucidate the possible role of BLU in the development of ESCC.

Research Area(s)

  • Animals, Carcinoma, Squamous Cell, Cell Line, Tumor, Chromosomes, Human, Pair 3, DNA Methylation, Down-Regulation, Esophageal Neoplasms, Gene Silencing, Genes, Tumor Suppressor, Humans, Mice, Mice, Nude, Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, Journal Article, Research Support, Non-U.S. Gov't

Citation Format(s)

Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas. / Yi Lo, Paulisally Hau; Chung Leung, Alfred Chi; Xiong, Wenjun; Law, Simon; Duh, Fuh-Mei; Lerman, Michael I; Stanbridge, Eric J; Lung, Maria Li.

In: Cancer Letters, Vol. 234, No. 2, 28.03.2006, p. 184-92.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review