Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas

Paulisally Hau Yi Lo; Alfred Chi Chung Leung; Wenjun Xiong; Simon Law; Fuh-Mei Duh; Michael I Lerman; Eric J Stanbridge; Maria Li Lung

doi:10.1016/j.canlet.2005.03.036

Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas

Paulisally Hau Yi Lo
, Alfred Chi Chung Leung
, Wenjun Xiong
, Simon Law
, Fuh-Mei Duh
, Michael I Lerman
, Eric J Stanbridge
, Maria Li Lung^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

31 Citations (Scopus)

Abstract

The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated. Reduced expression of BLU was detected in some ESCC cell lines and tumor tissues and the difference was quantitated by real-time quantitative polymerase chain reaction. Methylation specific-PCR revealed the down-regulation of BLU by epigenetic inactivation. However, exogenous expression of BLU did not functionally suppress tumorigenicity in nude mice. These results suggest that over-expression of BLU alone is not sufficient to inhibit tumorigenicity. Further studies on BLU interacting proteins are required to elucidate the possible role of BLU in the development of ESCC.

Original language	English
Pages (from-to)	184-192
Journal	Cancer Letters
Volume	234
Issue number	2
Online published	10 May 2005
DOIs	https://doi.org/10.1016/j.canlet.2005.03.036
Publication status	Published - 28 Mar 2006
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Animals
Carcinoma, Squamous Cell
Cell Line, Tumor
Chromosomes, Human, Pair 3
DNA Methylation
Down-Regulation
Esophageal Neoplasms
Gene Silencing
Genes, Tumor Suppressor
Humans
Mice
Mice, Nude
Reverse Transcriptase Polymerase Chain Reaction
Tumor Suppressor Proteins
Journal Article
Research Support, Non-U.S. Gov't

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10.1016/j.canlet.2005.03.036

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@article{b4f5af94e73a453683a65e4ac1a55f06,

title = "Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas",

abstract = "The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated. Reduced expression of BLU was detected in some ESCC cell lines and tumor tissues and the difference was quantitated by real-time quantitative polymerase chain reaction. Methylation specific-PCR revealed the down-regulation of BLU by epigenetic inactivation. However, exogenous expression of BLU did not functionally suppress tumorigenicity in nude mice. These results suggest that over-expression of BLU alone is not sufficient to inhibit tumorigenicity. Further studies on BLU interacting proteins are required to elucidate the possible role of BLU in the development of ESCC. {\textcopyright} 2005 Elsevier Ireland Ltd. All rights reserved.",

keywords = "Animals, Carcinoma, Squamous Cell, Cell Line, Tumor, Chromosomes, Human, Pair 3, DNA Methylation, Down-Regulation, Esophageal Neoplasms, Gene Silencing, Genes, Tumor Suppressor, Humans, Mice, Mice, Nude, Reverse Transcriptase Polymerase Chain Reaction, Tumor Suppressor Proteins, Journal Article, Research Support, Non-U.S. Gov't",

author = "\{Yi Lo\}, \{Paulisally Hau\} and \{Chung Leung\}, \{Alfred Chi\} and Wenjun Xiong and Simon Law and Fuh-Mei Duh and Lerman, \{Michael I\} and Stanbridge, \{Eric J\} and Lung, \{Maria Li\}",

year = "2006",

month = mar,

day = "28",

doi = "10.1016/j.canlet.2005.03.036",

language = "English",

volume = "234",

pages = "184--192",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas. / Yi Lo, Paulisally Hau; Chung Leung, Alfred Chi; Xiong, Wenjun et al.
In: Cancer Letters, Vol. 234, No. 2, 28.03.2006, p. 184-192.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

TY - JOUR

T1 - Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas

AU - Yi Lo, Paulisally Hau

AU - Chung Leung, Alfred Chi

AU - Xiong, Wenjun

AU - Law, Simon

AU - Duh, Fuh-Mei

AU - Lerman, Michael I

AU - Stanbridge, Eric J

AU - Lung, Maria Li

PY - 2006/3/28

Y1 - 2006/3/28

N2 - The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated. Reduced expression of BLU was detected in some ESCC cell lines and tumor tissues and the difference was quantitated by real-time quantitative polymerase chain reaction. Methylation specific-PCR revealed the down-regulation of BLU by epigenetic inactivation. However, exogenous expression of BLU did not functionally suppress tumorigenicity in nude mice. These results suggest that over-expression of BLU alone is not sufficient to inhibit tumorigenicity. Further studies on BLU interacting proteins are required to elucidate the possible role of BLU in the development of ESCC. © 2005 Elsevier Ireland Ltd. All rights reserved.

AB - The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated. Reduced expression of BLU was detected in some ESCC cell lines and tumor tissues and the difference was quantitated by real-time quantitative polymerase chain reaction. Methylation specific-PCR revealed the down-regulation of BLU by epigenetic inactivation. However, exogenous expression of BLU did not functionally suppress tumorigenicity in nude mice. These results suggest that over-expression of BLU alone is not sufficient to inhibit tumorigenicity. Further studies on BLU interacting proteins are required to elucidate the possible role of BLU in the development of ESCC. © 2005 Elsevier Ireland Ltd. All rights reserved.

KW - Animals

KW - Carcinoma, Squamous Cell

KW - Cell Line, Tumor

KW - Chromosomes, Human, Pair 3

KW - DNA Methylation

KW - Down-Regulation

KW - Esophageal Neoplasms

KW - Gene Silencing

KW - Genes, Tumor Suppressor

KW - Humans

KW - Mice

KW - Mice, Nude

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Tumor Suppressor Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

UR - https://www.scopus.com/pages/publications/33645014254

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-33645014254&origin=recordpage

U2 - 10.1016/j.canlet.2005.03.036

DO - 10.1016/j.canlet.2005.03.036

M3 - RGC 21 - Publication in refereed journal

C2 - 15885884

SN - 0304-3835

VL - 234

SP - 184

EP - 192

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas

Abstract

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