Expression and spatial distribution of secretin and secretin receptor in human cerebellum

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)219-222
Journal / PublicationNeuroReport
Volume16
Issue number3
Publication statusPublished - 28 Feb 2005
Externally publishedYes

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-14944344753&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(b3bbd144-140c-402a-9a11-1679c09792d8).html

Abstract

The expression and spatial distribution of secretin and its receptor in human cerebellum were investigated by in situ hybridization and immunohistochemical techniques. Secretin mRNAs are found in Purkinje cells whereas secretin receptor transcripts are present in Purkinje cells and basket cells in the molecular cell layer. In addition, secretin-immunoreactivities are localized in both the soma and dendrites of Purkinje cells. These data are the first demonstration of the spatial distribution of secretin and its receptor in distinct neurons within the human cerebellum. The cellular localizations of this ligand-receptor pair are consistent with the proposed actions of secretin in the cerebellum of rodents and hence suggest that secretin also serves specific neural functions in the human cerebellum. © 2005 Lippincott Williams & Wilkins.

Research Area(s)

  • Human cerebellum, Purkinje cells, Secretin, Secretin receptor

Bibliographic Note

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receptors INIS
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humans INIS
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spatial distributio... INIS
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cerebellum INIS
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secretin INIS
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Spatial Distributio... Keyphrases
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Secretin Keyphrases
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Secretin Receptor Keyphrases
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Expression Distribu... Keyphrases
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Human Cerebellum Keyphrases
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Citation Format(s)

[ RIS ] [ BibTeX ]
Expression and spatial distribution of secretin and secretin receptor in human cerebellum. / Lee, S. M.Y.; Yung, W. H.; Chen, L. et al.
In: NeuroReport, Vol. 16, No. 3, 28.02.2005, p. 219-222.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review