Experimental study on the deformation of erythrocytes under optically trapping and stretching

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)128-133
Journal / PublicationMaterials Science and Engineering A
Volume423
Issue number1-2
Publication statusPublished - 15 May 2006
Externally publishedYes

Abstract

The mechanical behavior of erythrocytes is studied experimentally and numerically. In the experiment, prepared silica microbeads are attached to the surface of spherically swollen erythrocytes (red blood cells, RBCs) at room temperature (25 °C). The cells are then stretched by single laser beam via the microbeads. The relation of deformation and stretching force is quantitatively assessed by the image processing of digital pictures. Meanwhile, a physical model for an axisymmetric cell is introduced to study its deformation by different level of stretching force. By comparing the experimental and numerical data, stiffness of the cell membrane can be determined and the optimal values are found to agree with other studies by different techniques such as micropipette aspiration or high frequency electric field. © 2006 Elsevier B.V. All rights reserved.

Research Area(s)

  • Cell membrane, Erythrocyte, Optical tweezers, Stiffness modulus