Experimental reproduction of proliferative enteropathy and the role of IFN-γ in protective immunity against Lawsonia intracellularis in mice

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

12 Scopus Citations
View graph of relations

Author(s)

  • Jeong-Keun Lee
  • Jeong-Yong Ye
  • Joong-Bok Lee
  • Seung-Yong Park
  • Chang-Seon Song
  • Soo-Ki Kim
  • In-Soo Choi

Detail(s)

Original languageEnglish
Pages (from-to)357-359
Journal / PublicationJournal of Veterinary Science
Volume6
Issue number4
Publication statusPublished - Dec 2005
Externally publishedYes

Abstract

Proliferative enteropathy was reproduced in IFN-γ receptor knockout (IFN-γ R-) mice by experimental infection with Lawsonia intracellularis (L. intracellularis). The cecum and the colon of the infected mice were evidently enlarged 2 weeks post infection. The presence of L. intracellularis was identified in the stool and the cecum of the mice after infection. However, high levels of IFN-γ were detected in the sera of the infected mice 2 weeks PI. These data indicated that the IFN-γ produced in the infected mice should have been utilized by it's receptor to elicit protective immune responses against L. intracellularis infections.

Research Area(s)

  • IFN-γ, IFN-γ R- mice, Lawsonia intracellularis, Proliferative enteropathy

Citation Format(s)

Experimental reproduction of proliferative enteropathy and the role of IFN-γ in protective immunity against Lawsonia intracellularis in mice. / Go, Yun-Young; Lee, Jeong-Keun; Ye, Jeong-Yong; Lee, Joong-Bok; Park, Seung-Yong; Song, Chang-Seon; Kim, Soo-Ki; Choi, In-Soo.

In: Journal of Veterinary Science, Vol. 6, No. 4, 12.2005, p. 357-359.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review