Exosomes in Tumor Angiogenesis—Multifunctional Messengers With Mixed Intentions

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)12_Chapter in an edited book (Author)

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Detail(s)

Original languageEnglish
Title of host publicationDiagnostic and Therapeutic Applications of Exosomes in Cancer
EditorsMansoor Amiji, Rajagopal Ramesh
PublisherAcademic Press
Chapter13
Pages235-245
Edition1st
ISBN (Electronic)9780128128046
ISBN (Print)978-0-12-812774-2
Publication statusPublished - 11 May 2018

Abstract

Tumor angiogenesis has been a primary target as well as a key challenge in cancer treatment. A central factor underlying tumor angiogenesis is the balance between pro- and antiangiogenic signals, which is the result of the dynamic communication between cancer cells and the tumor microenvironment. Exosomes have emerged as a robust platform that mediates cell–cell communication in many biological contexts. Here, we review the research that have revealed the important roles of exosomes in tumor angiogenesis. We emphasize that exosomes are heterogeneous in terms of their angiogenic activities, depending on their cellular origin, molecular contents, and functional contexts. We suggest that innovative approaches to develop exosome-based targeting or delivery tools, harnessing the unique properties of the exosomes in regulating tumor angiogenesis, will foster progress in cancer therapy.

Research Area(s)

  • Antiangiogenesis, Endothelial cells, Exosome, miRNA, Tumor angiogenesis

Bibliographic Note

Research Unit(s) information for this publication is provided by the author(s) concerned.

Citation Format(s)

Exosomes in Tumor Angiogenesis—Multifunctional Messengers With Mixed Intentions. / ZHANG, Liang.

Diagnostic and Therapeutic Applications of Exosomes in Cancer. ed. / Mansoor Amiji; Rajagopal Ramesh. 1st. ed. Academic Press, 2018. p. 235-245.

Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45)12_Chapter in an edited book (Author)