Exosomes derived from magnesium ion-stimulated macrophages inhibit angiogenesis

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

View graph of relations

Author(s)

  • Ruiqiang Hang
  • Xue Tian
  • Guangping Qu
  • Yuyu Zhao
  • Runhua Yao
  • Yi Zhang
  • Wenfa Wei
  • Xiaohong Yao

Detail(s)

Original languageEnglish
Article number045008
Journal / PublicationBiomedical Materials (Bristol)
Volume17
Issue number4
Online published13 May 2022
Publication statusPublished - Jul 2022

Abstract

Angiogenesis, an essential prerequisite to osteogenesis in bone repair and regeneration, can be mediated by immunoregulation of macrophages. Magnesium and its alloys are promising biodegradable bone implant materials and can affect immunoregulation of macrophages by the degradation products (magnesium ions). Nevertheless, the mechanism of macrophage-derived exosomes stimulated by Mg ions in immunoregulation is still not well understood. Herein, 10-50 mM magnesium ions are shown to inhibit the macrophage viability and proliferation in a dose-dependent manner, but a high concentration results in macrophage apoptosis. The exosomes secreted by macrophages from magnesium ion stimulation inhibit angiogenesis of endothelial cells, as manifested by the suppressed cell viability, proliferation, migration, and tube formation, which arise at least partially from exosome-mediated downregulation of endothelial nitric oxide and the vascular endothelial growth factor. The findings reported in this paper suggest that the bio-functionality of biodegradable magnesium alloys must be considered from the perspective of immunoregulation of macrophage-derived exosomes. Our results also suggest potential cancer therapy by inhibiting tumor-associated angiogenesis.

Research Area(s)

  • angiogenesis, exosomes, immunoregulation, macrophages, magnesium

Citation Format(s)

Exosomes derived from magnesium ion-stimulated macrophages inhibit angiogenesis. / Hang, Ruiqiang; Tian, Xue; Qu, Guangping; Zhao, Yuyu; Yao, Runhua; Zhang, Yi; Wei, Wenfa; Yao, Xiaohong; Chu, Paul K.

In: Biomedical Materials (Bristol), Vol. 17, No. 4, 045008, 07.2022.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review