Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

119 Scopus Citations
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Author(s)

  • Leiluo Geng
  • Boya Liao
  • Leigang Jin
  • Zhe Huang
  • Chris R. Triggle
  • Hong Ding
  • Jialiang Zhang
  • Zhuofeng Lin
  • Aimin Xu

Detail(s)

Original languageEnglish
Pages (from-to)2738-2752.e4
Journal / PublicationCell Reports
Volume26
Issue number10
Publication statusPublished - 5 Mar 2019
Externally publishedYes

Link(s)

Abstract

Geng et al. identify FGF21 signaling in adipose tissues as an obligatory molecular transducer of exercise, conferring its metabolic benefits on systemic glucose and lipid metabolism and insulin sensitivity. Exercise sensitizes FGF21 actions in adipose tissues, which in turns sends humoral signals to coordinate multi-organ crosstalk for maintaining metabolic homeostasis.

Research Area(s)

  • adipokines, adipose tissue, exercise, FGF21, FGFR1, KLB, metabolic regulation, obesity, PPARγ

Bibliographic Note

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Citation Format(s)

Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. / Geng, Leiluo; Liao, Boya; Jin, Leigang et al.
In: Cell Reports, Vol. 26, No. 10, 05.03.2019, p. 2738-2752.e4.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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