Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues

Leiluo Geng; Boya Liao; Leigang Jin; Zhe Huang; Chris R. Triggle; Hong Ding; Jialiang Zhang; Yu Huang; Zhuofeng Lin; Aimin Xu

doi:10.1016/j.celrep.2019.02.014

Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues

Leiluo Geng
, Boya Liao
, Leigang Jin
, Zhe Huang
, Chris R. Triggle
, Hong Ding
, Jialiang Zhang
, Yu Huang
, Zhuofeng Lin^*
, Aimin Xu

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

183 Citations (Scopus)

55 Downloads (CityUHK Scholars)

Abstract

Geng et al. identify FGF21 signaling in adipose tissues as an obligatory molecular transducer of exercise, conferring its metabolic benefits on systemic glucose and lipid metabolism and insulin sensitivity. Exercise sensitizes FGF21 actions in adipose tissues, which in turns sends humoral signals to coordinate multi-organ crosstalk for maintaining metabolic homeostasis.

Original language	English
Pages (from-to)	2738-2752.e4
Journal	Cell Reports
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2019.02.014
Publication status	Published - 5 Mar 2019
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

adipokines
adipose tissue
exercise
FGF21
FGFR1
KLB
metabolic regulation
obesity
PPARγ

Publisher's Copyright Statement

This full text is made available under CC-BY-NC-ND 4.0. https://creativecommons.org/licenses/by-nc-nd/4.0/

Access Output

10.1016/j.celrep.2019.02.014

86055799.pdfFinal Published version, 3.31 MBLicence: CC BY-NC-ND

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@article{63e4f085b0854c929e42890039ae0f4a,

title = "Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues",

abstract = "Geng et al. identify FGF21 signaling in adipose tissues as an obligatory molecular transducer of exercise, conferring its metabolic benefits on systemic glucose and lipid metabolism and insulin sensitivity. Exercise sensitizes FGF21 actions in adipose tissues, which in turns sends humoral signals to coordinate multi-organ crosstalk for maintaining metabolic homeostasis.",

keywords = "adipokines, adipose tissue, exercise, FGF21, FGFR1, KLB, metabolic regulation, obesity, PPARγ",

author = "Leiluo Geng and Boya Liao and Leigang Jin and Zhe Huang and Triggle, \{Chris R.\} and Hong Ding and Jialiang Zhang and Yu Huang and Zhuofeng Lin and Aimin Xu",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].",

year = "2019",

month = mar,

day = "5",

doi = "10.1016/j.celrep.2019.02.014",

language = "English",

volume = "26",

pages = "2738--2752.e4",

journal = "Cell Reports",

issn = "2639-1856",

publisher = "Elsevier B.V.",

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}

TY - JOUR

T1 - Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues

AU - Geng, Leiluo

AU - Liao, Boya

AU - Jin, Leigang

AU - Huang, Zhe

AU - Triggle, Chris R.

AU - Ding, Hong

AU - Zhang, Jialiang

AU - Huang, Yu

AU - Lin, Zhuofeng

AU - Xu, Aimin

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2019/3/5

Y1 - 2019/3/5

N2 - Geng et al. identify FGF21 signaling in adipose tissues as an obligatory molecular transducer of exercise, conferring its metabolic benefits on systemic glucose and lipid metabolism and insulin sensitivity. Exercise sensitizes FGF21 actions in adipose tissues, which in turns sends humoral signals to coordinate multi-organ crosstalk for maintaining metabolic homeostasis.

AB - Geng et al. identify FGF21 signaling in adipose tissues as an obligatory molecular transducer of exercise, conferring its metabolic benefits on systemic glucose and lipid metabolism and insulin sensitivity. Exercise sensitizes FGF21 actions in adipose tissues, which in turns sends humoral signals to coordinate multi-organ crosstalk for maintaining metabolic homeostasis.

KW - adipokines

KW - adipose tissue

KW - exercise

KW - FGF21

KW - FGFR1

KW - KLB

KW - metabolic regulation

KW - obesity

KW - PPARγ

UR - https://www.scopus.com/pages/publications/85061657633

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85061657633&origin=recordpage

U2 - 10.1016/j.celrep.2019.02.014

DO - 10.1016/j.celrep.2019.02.014

M3 - RGC 21 - Publication in refereed journal

C2 - 30840894

SN - 2639-1856

VL - 26

SP - 2738-2752.e4

JO - Cell Reports

JF - Cell Reports

IS - 10

ER -

Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues

Abstract

Bibliographical note

UN SDGs

Research Keywords

Publisher's Copyright Statement

Access Output

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