Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and 1O2 generation

Jie Pan; Lijun Jiang; Chi-Fai Chan; Tik-Hung Tsoi; Kwok-Keung Shiu; Daniel W.J. Kwong; Wing-Tak Wong; Wai-Kwok Wong; Ka-Leung Wong

doi:10.1016/j.jlumin.2016.12.024

Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and ¹O₂ generation

Jie Pan
, Lijun Jiang
, Chi-Fai Chan
, Tik-Hung Tsoi
, Kwok-Keung Shiu
, Daniel W.J. Kwong
, Wing-Tak Wong
, Wai-Kwok Wong
, Ka-Leung Wong

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

18 Citations (Scopus)

Abstract

Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) moiety improves the water solubility and cell permeability. Consider the similar excited state energies between Ru(polypyridyl) and porphyrin moieties; a small perturbation (e.g. Zn(II) metalation) would lead to a marked change in the energy migration process. In this work, we have synthesized a series of porphyrins conjugated with Ru(polypyridyl) complexes using different linkers and investigated their photophysical properties, which included singlet oxygen quantum yield and their in vitro biological properties, resulting from linker variation and porphyrin modification by Zn(II) metalation. © 2016

Original language	English
Pages (from-to)	89-95
Journal	Journal of Luminescence
Volume	184
DOIs	https://doi.org/10.1016/j.jlumin.2016.12.024
Publication status	Published - 1 Apr 2017
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This work was funded by grants from The Hong Kong Research Grants Council (HKBU 203112), EPSRC, HKBU-HK PolyU Joint Research Programme (RC-ICRS/15-16/02F-WKL02F-WKL and RC-ICRS/15-16/02D-KWJ) and Prospective Joint Research Project (BY2015042-01).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Fluorescence probe
Luminescent material
Photodynamic therapy
Porphyrin
Ruthenium

RGC Funding Information

RGC-funded

Access Output

10.1016/j.jlumin.2016.12.024

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Permanent Link

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Cite this

@article{e649569e99e94da0b9297e2d1800f264,

title = "Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and 1O2 generation",

abstract = "Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) moiety improves the water solubility and cell permeability. Consider the similar excited state energies between Ru(polypyridyl) and porphyrin moieties; a small perturbation (e.g. Zn(II) metalation) would lead to a marked change in the energy migration process. In this work, we have synthesized a series of porphyrins conjugated with Ru(polypyridyl) complexes using different linkers and investigated their photophysical properties, which included singlet oxygen quantum yield and their in vitro biological properties, resulting from linker variation and porphyrin modification by Zn(II) metalation. {\textcopyright} 2016",

keywords = "Fluorescence probe, Luminescent material, Photodynamic therapy, Porphyrin, Ruthenium",

author = "Jie Pan and Lijun Jiang and Chi-Fai Chan and Tik-Hung Tsoi and Kwok-Keung Shiu and Kwong, \{Daniel W.J.\} and Wing-Tak Wong and Wai-Kwok Wong and Ka-Leung Wong",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].",

year = "2017",

month = apr,

day = "1",

doi = "10.1016/j.jlumin.2016.12.024",

language = "English",

volume = "184",

pages = "89--95",

journal = "Journal of Luminescence",

issn = "0022-2313",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Excitation energy transfer in ruthenium (II)-porphyrin conjugates led to enhanced emission quantum yield and 1O2 generation

AU - Pan, Jie

AU - Jiang, Lijun

AU - Chan, Chi-Fai

AU - Tsoi, Tik-Hung

AU - Shiu, Kwok-Keung

AU - Kwong, Daniel W.J.

AU - Wong, Wing-Tak

AU - Wong, Wai-Kwok

AU - Wong, Ka-Leung

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) moiety improves the water solubility and cell permeability. Consider the similar excited state energies between Ru(polypyridyl) and porphyrin moieties; a small perturbation (e.g. Zn(II) metalation) would lead to a marked change in the energy migration process. In this work, we have synthesized a series of porphyrins conjugated with Ru(polypyridyl) complexes using different linkers and investigated their photophysical properties, which included singlet oxygen quantum yield and their in vitro biological properties, resulting from linker variation and porphyrin modification by Zn(II) metalation. © 2016

AB - Porphyrins are good photodynamic therapy (PDT) agents due to its flexibility for modifications to achieve tumor localization and photo-cytotoxicity against cancer. Yet they are not perfect. In a Ru(polypyridyl)-porphyrin system, the Ru(polypyridyl) moiety improves the water solubility and cell permeability. Consider the similar excited state energies between Ru(polypyridyl) and porphyrin moieties; a small perturbation (e.g. Zn(II) metalation) would lead to a marked change in the energy migration process. In this work, we have synthesized a series of porphyrins conjugated with Ru(polypyridyl) complexes using different linkers and investigated their photophysical properties, which included singlet oxygen quantum yield and their in vitro biological properties, resulting from linker variation and porphyrin modification by Zn(II) metalation. © 2016

KW - Fluorescence probe

KW - Luminescent material

KW - Photodynamic therapy

KW - Porphyrin

KW - Ruthenium

UR - https://www.scopus.com/pages/publications/85007152035

UR - https://www.scopus.com/pages/publications/85007152035#tab=impact

U2 - 10.1016/j.jlumin.2016.12.024

DO - 10.1016/j.jlumin.2016.12.024

M3 - RGC 21 - Publication in refereed journal

SN - 0022-2313

VL - 184

SP - 89

EP - 95

JO - Journal of Luminescence

JF - Journal of Luminescence

ER -