Evolution of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae by Acquisition of blaVIM-1-Bearing Plasmid

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

3 Scopus Citations
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Author(s)

  • Ning Dong
  • Qiaoling Sun
  • Yonglu Huang
  • Lingbin Shu
  • Lianwei Ye
  • Rong Zhang

Detail(s)

Original languageEnglish
Article numbere01056-19
Journal / PublicationAntimicrobial Agents and Chemotherapy
Volume63
Issue number9
Online published23 Aug 2019
Publication statusPublished - Sep 2019
Externally publishedYes

Abstract

We report the identification of a carbapenem-resistant, hypervirulent Klebsiella pneumoniae (hvKp) strain which produced the carbapenemase VIM-1. Genomic analysis showed that the strain belonged to sequence type ST23 and serotype K1, a major hvKp clone, and harbored three resistance-encoding plasmids. Among them, a blaVIM-1-bearing plasmid was found to possess a mosaic structure presumably generated by multiple gene mobilization events. This finding indicates that hvKp actively acquires mobile resistance-encoding elements, facilitating simultaneous expression of hypervirulence and carbapenem-resistance.

Research Area(s)

  • Carbapenem resistance, Hypervirulence, Klebsiella pneumoniae, VIM

Citation Format(s)

Evolution of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae by Acquisition of blaVIM-1-Bearing Plasmid. / Dong, Ning; Sun, Qiaoling; Huang, Yonglu; Shu, Lingbin; Ye, Lianwei; Zhang, Rong; Chen, Sheng.

In: Antimicrobial Agents and Chemotherapy, Vol. 63, No. 9, e01056-19, 09.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal