Evidence that nitrous oxide can maintain anaesthesia after induction with barbiturates

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • M. J. DONAGHY
  • L. MAFFEI
  • J. A. MOVSHON
  • D. ROSE
  • R. C. VAN SLUYTERS

Detail(s)

Original languageEnglish
Pages (from-to)39P-41P
Journal / PublicationJournal of Physiology
Volume237
Issue numberSuppl
Online published1 Dec 1974
Publication statusPublished - 1 Dec 1974
Externally publishedYes

Abstract

Three cats were prepared under short acting barbiturate methohexital: approximately 30 mg/kg, given i.v., as required, over about 1.5 hr). Each cat was then paralyzed by continuous infusion of gallamine (7.5 mg/kg.hr) and artificially ventilated with 80% N2O/19% O2/1% CO2. The electroencephalogram, electrocardiogram and expired PCO2 were monitored throughout the ensuing neurophysiological experiment. Maximum PCO2 was held at 4%. Apart from a reduction in E.E.G. spindling there was no discernible change throughout the 30-32 hr of the experiments. Even a firm pinch to the forepaw failed to desynchronize the E.E.G. However, desynchronization did occur if the concentration of N2O was reduced to 65% but did not if it was raised again to 80%. After 28-29 hr relaxant infusion was stopped: 1-2 hr later each cat was able to breathe the N2O mixture for itself. In this unparalyzed state the animals were still adequately anesthetized, having very little spontaneous movement and only a weak withdrawal reflex. Finally, after 30-32 hr, a light dose of methohexital (3 mg/kg) did not affect the E.E.G. although larger doses did cause barbiturate spindling.

Citation Format(s)

Evidence that nitrous oxide can maintain anaesthesia after induction with barbiturates. / BLAKEMORE, C.; DONAGHY, M. J.; MAFFEI, L.; MOVSHON, J. A.; ROSE, D.; VAN SLUYTERS, R. C.

In: Journal of Physiology, Vol. 237, No. Suppl, 01.12.1974, p. 39P-41P.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal