Evaluation of Ni-free Zr-Cu-Fe-Al bulk metallic glass for biomedical implant applications

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

14 Scopus Citations
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Author(s)

  • Ying-Sui Sun
  • Wei Zhang
  • Wu Kai
  • Peter K. Liaw
  • Her-Hsiung Huang

Detail(s)

Original languageEnglish
Pages (from-to)S539-S543
Journal / PublicationJournal of Alloys and Compounds
Volume586
Issue numberSupplement 1
Early online date24 Jan 2013
Publication statusPublished - 15 Feb 2014
Externally publishedYes

Abstract

This study was conducted to investigate the surface characteristics, including the chemical composition, metal ion release, protein adsorption, and cell adhesion, of a Ni-free Zr-based (Zr62.5Cu22.5Fe 5Al10) bulk metallic glass (BMG) with low elastic modulus for biomedical implant applications. X-ray photoelectron spectroscopy was used to identify the surface chemical composition and the protein (albumin and fibronectin) adsorption of the specimen. The metal ions released from the specimen in simulated blood plasma and artificial saliva solutions were measured using an inductively coupled plasma-mass spectrometer. The cell adhesion, in terms of the morphology, focal adhesion complex, and skeletal arrangement, of human bone marrow mesenchymal stem cells was evaluated using scanning electron microscope observations and immunofluorescent staining. For comparison purposes, the above-mentioned tests were also carried out on the widely used biomedical metal, Ti. The results showed that the main component on the outermost surface of the amorphous Zr62.5Cu22.5Fe5Al10 BMG was ZrO2 with small amounts of Cu, Al, and Fe oxides. The released metal ions from Zr62.5Cu22.5Fe5Al 10 BMG were well below the critical concentrations that cause negative biological effects. The Zr62.5Cu22.5Fe 5Al10 BMG had a greater adsorption capacity for albumin and fibronectin than that of commercial biomedical Ti. The Zr 62.5Cu22.5Fe5Al10 BMG surface showed an attached cell number similar to the Ti surface but had better cell adhesion morphology and cytoskeletal arrangement. Based on the present results, the Ni-free Zr62.5Cu22.5Fe5Al10 BMG has the potential to be used for biomedical implant applications.  

Research Area(s)

  • Biomedical applications, Cell adhesion, Ion release, Ni-free Zr-based bulk metallic glass, Protein adsorption

Citation Format(s)

Evaluation of Ni-free Zr-Cu-Fe-Al bulk metallic glass for biomedical implant applications. / Sun, Ying-Sui; Zhang, Wei; Kai, Wu; Liaw, Peter K.; Huang, Her-Hsiung.

In: Journal of Alloys and Compounds, Vol. 586, No. Supplement 1, 15.02.2014, p. S539-S543.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review