Et3N mediated synthesis of polysubstituted thiophenes from α-oxo ketene dithioacetals

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Xiaoli Kan
  • Xiaobing Yang
  • Fangzhong Hu
  • Yang Wang
  • Ying Liu
  • Xiaomao Zou
  • Hengyu Li
  • Hao Li

Detail(s)

Original languageEnglish
Pages (from-to)6198-6201
Journal / PublicationTetrahedron Letters
Volume56
Issue number45
Online published28 Sep 2015
Publication statusPublished - 4 Nov 2015
Externally publishedYes

Abstract

In this Letter, an efficient synthetic route to prepare polysubstituted thiophene derivatives was achieved via the Et3N-mediated (Claisen) rearrangement reaction from α-oxo S-methyl-S-propargyl ketenes, which were obtained through alkylation of β-oxodithioesters with propargylic bromides, followed by regioselective intramolecular cyclization.

Research Area(s)

  • Cyclization, Et3N mediation, Polysubstituted thiophenes, α-Oxo S-methyl-S-propargyl ketenes

Citation Format(s)

Et3N mediated synthesis of polysubstituted thiophenes from α-oxo ketene dithioacetals. / Kan, Xiaoli; Yang, Xiaobing; Hu, Fangzhong; Wang, Yang; Liu, Ying; Zou, Xiaomao; Li, Hengyu; Li, Hao; Zhang, Qichun.

In: Tetrahedron Letters, Vol. 56, No. 45, 04.11.2015, p. 6198-6201.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review