Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)39-51
Number of pages13
Journal / PublicationJournal of Endocrinology
Volume245
Issue number1
Online published24 Jan 2020
Publication statusPublished - Apr 2020

Link(s)

Abstract

Sexual differences have been observed in the onset and prognosis of human cardiovascular diseases, but the underlying mechanisms are not clear. Here, we found that zebrafish heart regeneration is faster in females, can be accelerated by estrogen and is suppressed by the estrogen-antagonist tamoxifen. Injuries to the zebrafish heart, but not other tissues, increased plasma estrogen levels and the expression of estrogen receptors, especially esr2a. The resulting endocrine disruption induces the expression of the female-specific protein vitellogenin in male zebrafish. Transcriptomic analyses suggested heart injuries triggered pronounced immune and inflammatory responses in females. These responses, previously shown to elicit heart regeneration, could be enhanced by estrogen treatment in males and reduced by tamoxifen in females. Furthermore, a prior exposure to estrogen preconditioned the zebrafish heart for an accelerated regeneration. Altogether, this study reveals that heart regeneration is modulated by an estrogen-inducible inflammatory response to cardiac injury. These findings elucidate a previously unknown layer of control in zebrafish heart regeneration and provide a new model system for the study of sexual differences in human cardiac repair.

Research Area(s)

  • sexually dimorphic, heart regeneration, estrogen, estrogen receptor, inflammation

Citation Format(s)

Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish. / Xu, Shisan; Xie, Fangjing; Tian, Li; Fallah, Samane; Babaei, Fatemeh; Manno, Sinai H C; Manno III, Francis A M; Zhu, Lina; Wong, Kin Fung ; Liang, Yimin; Ramalingam, Rajkumar; Sun, Lei; Wang, Xin; Plumb, Robert; Lee, Gethings; Lam, Yun Wah; Cheng, Shuk Han.

In: Journal of Endocrinology, Vol. 245, No. 1, 04.2020, p. 39-51.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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