Estimation of the Oxidative Stress and Molecular Damage Caused by 1-Butyl-3-Methylimidazolium Bromide Ionic Liquid in Zebrafish Livers

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

13 Scopus Citations
View graph of relations

Author(s)

  • Tong Liu
  • Jinhua Wang
  • Jun Wang
  • Lusheng Zhu
  • Jun Zhang

Detail(s)

Original languageEnglish
Pages (from-to)232-238
Journal / PublicationJournal of Biochemical and Molecular Toxicology
Volume30
Issue number5
Online published17 Dec 2015
Publication statusPublished - May 2016

Abstract

The present study investigated the toxic effects of 1-butyl-3-methylimidazolium bromide ([C4mim]Br) in zebrafish livers after exposure to 5-40 mg/L of [C4mim]Br on days 7, 14, 21, and 28. The results showed that low levels of [C4mim]Br exposure activated the superoxide dismutase (SOD) activity during early periods of exposure. However, high concentrations (20-40 mg/L) of [C4mim]Br caused the inhibition of SOD, which, accordingly, led to excess reactive oxygen species and malondialdehyde. The present results indicate that [C4mim]Br causes oxidative stress in the livers of both male and female zebrafish. Additionally, the DNA damage revealed that [C4mim]Br has a genotoxic effect on zebrafish livers, even when the concentration of [C4mim]Br is low (5 mg/L). The DNA damage was demonstrated by quantifying the DNA strand breakage.

Research Area(s)

  • HPLC, MDA, DNA Damage, ROS, SOD

Citation Format(s)

Estimation of the Oxidative Stress and Molecular Damage Caused by 1-Butyl-3-Methylimidazolium Bromide Ionic Liquid in Zebrafish Livers. / Dong, Miao; Liu, Tong; Wang, Jinhua et al.
In: Journal of Biochemical and Molecular Toxicology, Vol. 30, No. 5, 05.2016, p. 232-238.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review