Essential functions of miR-125b in cancer
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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Detail(s)
Original language | English |
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Article number | e12913 |
Journal / Publication | Cell Proliferation |
Volume | 54 |
Issue number | 2 |
Online published | 17 Dec 2020 |
Publication status | Published - Feb 2021 |
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DOI | DOI |
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Attachment(s) | Documents
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Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85097629908&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(ed8d52ed-ec75-479e-bea0-1f29f4bd8067).html |
Abstract
MicroRNAs (miRNAs) are small and highly conserved non-coding RNAs that silence target mRNAs, and compelling evidence suggests that they play an essential role in the pathogenesis of human diseases, especially cancer. miR-125b, which is the mammalian orthologue of the first discovered miRNA lin-4 in Caenorhabditis elegans, is one of the most important miRNAs that regulate various physiological and pathological processes. The role of miR-125b in many types of cancer has been well established, and so here we review the current knowledge of how miR-125b is deregulated in different types of cancer; its oncogenic and/or tumour-suppressive roles in tumourigenesis and cancer progression; and its regulation with regard to treatment response, all of which are underlined in multiple studies. The emerging information that elucidates the essential functions of miR-125b might help support its potentiality as a diagnostic and prognostic biomarker as well as an effective therapeutic tool against cancer.
Research Area(s)
- biomarker, cancer, chemoresistance, microRNA, miR-125b
Citation Format(s)
Essential functions of miR-125b in cancer. / Peng, Boya; Theng, Poh Ying; Le, Minh T. N.
In: Cell Proliferation, Vol. 54, No. 2, e12913, 02.2021.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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