Essential functions of miR-125b in cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Article numbere12913
Journal / PublicationCell Proliferation
Volume54
Issue number2
Online published17 Dec 2020
Publication statusPublished - Feb 2021

Link(s)

Abstract

MicroRNAs (miRNAs) are small and highly conserved non-coding RNAs that silence target mRNAs, and compelling evidence suggests that they play an essential role in the pathogenesis of human diseases, especially cancer. miR-125b, which is the mammalian orthologue of the first discovered miRNA lin-4 in Caenorhabditis elegans, is one of the most important miRNAs that regulate various physiological and pathological processes. The role of miR-125b in many types of cancer has been well established, and so here we review the current knowledge of how miR-125b is deregulated in different types of cancer; its oncogenic and/or tumour-suppressive roles in tumourigenesis and cancer progression; and its regulation with regard to treatment response, all of which are underlined in multiple studies. The emerging information that elucidates the essential functions of miR-125b might help support its potentiality as a diagnostic and prognostic biomarker as well as an effective therapeutic tool against cancer.

Research Area(s)

  • biomarker, cancer, chemoresistance, microRNA, miR-125b

Citation Format(s)

Essential functions of miR-125b in cancer. / Peng, Boya; Theng, Poh Ying; Le, Minh T. N.

In: Cell Proliferation, Vol. 54, No. 2, e12913, 02.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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