Essential functions of miR-125b in cancer

Boya Peng; Poh Ying Theng; Minh T. N. Le

doi:10.1111/cpr.12913

Essential functions of miR-125b in cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

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16 Scopus Citations

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Author(s)

Boya Peng
Poh Ying Theng
Minh T. N. Le

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Detail(s)

Original language	English
Article number	e12913
Journal / Publication	Cell Proliferation
Volume	54
Issue number	2
Online published	17 Dec 2020
Publication status	Published - Feb 2021

Link(s)

DOI	DOI https://doi.org/10.1111/cpr.12913 Final Published version
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Attachment(s)	Documents 57691284.pdf Final Published version, 1.51 MB, PDF Publisher's Copyright Statement This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85097629908&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(ed8d52ed-ec75-479e-bea0-1f29f4bd8067).html

Abstract

MicroRNAs (miRNAs) are small and highly conserved non-coding RNAs that silence target mRNAs, and compelling evidence suggests that they play an essential role in the pathogenesis of human diseases, especially cancer. miR-125b, which is the mammalian orthologue of the first discovered miRNA lin-4 in Caenorhabditis elegans, is one of the most important miRNAs that regulate various physiological and pathological processes. The role of miR-125b in many types of cancer has been well established, and so here we review the current knowledge of how miR-125b is deregulated in different types of cancer; its oncogenic and/or tumour-suppressive roles in tumourigenesis and cancer progression; and its regulation with regard to treatment response, all of which are underlined in multiple studies. The emerging information that elucidates the essential functions of miR-125b might help support its potentiality as a diagnostic and prognostic biomarker as well as an effective therapeutic tool against cancer.