Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 85-88 |
Journal / Publication | The Veterinary Journal |
Volume | 210 |
Online published | 29 Dec 2015 |
Publication status | Published - Apr 2016 |
Externally published | Yes |
Link(s)
Abstract
Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data indicate that EHV1 employs different and still unresolved mechanisms to induce down-regulation of several functionally important cell surface proteins on equine DC.
Research Area(s)
- Down-regulation, Equine herpesvirus 1, Monocyte-derived dendritic cells, PUL56
Citation Format(s)
Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells. / Claessen, Christophe; De Lange, Valérie; Huang, Teng et al.
In: The Veterinary Journal, Vol. 210, 04.2016, p. 85-88.
In: The Veterinary Journal, Vol. 210, 04.2016, p. 85-88.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review