Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells

Christophe Claessen; Valérie De Lange; Teng Huang; Guanggang Ma; Nikolaus Osterrieder; Herman Favoreel; Gerlinde R. Van de Walle

doi:10.1016/j.tvjl.2015.12.008

Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells

Christophe Claessen, Valérie De Lange, Teng Huang, Guanggang Ma, Nikolaus Osterrieder, Herman Favoreel, Gerlinde R. Van de Walle^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

2 Citations (Scopus)

Abstract

Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data indicate that EHV1 employs different and still unresolved mechanisms to induce down-regulation of several functionally important cell surface proteins on equine DC.

Original language	English
Pages (from-to)	85-88
Journal	The Veterinary Journal
Volume	210
Online published	29 Dec 2015
DOIs	https://doi.org/10.1016/j.tvjl.2015.12.008
Publication status	Published - Apr 2016
Externally published	Yes

Research Keywords

Down-regulation
Equine herpesvirus 1
Monocyte-derived dendritic cells
PUL56

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10.1016/j.tvjl.2015.12.008

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title = "Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells",

abstract = "Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data indicate that EHV1 employs different and still unresolved mechanisms to induce down-regulation of several functionally important cell surface proteins on equine DC.",

keywords = "Down-regulation, Equine herpesvirus 1, Monocyte-derived dendritic cells, PUL56, Down-regulation, Equine herpesvirus 1, Monocyte-derived dendritic cells, PUL56, Down-regulation, Equine herpesvirus 1, Monocyte-derived dendritic cells, PUL56",

author = "Christophe Claessen and {De Lange}, Val{\'e}rie and Teng Huang and Guanggang Ma and Nikolaus Osterrieder and Herman Favoreel and {Van de Walle}, {Gerlinde R.}",

year = "2016",

month = apr,

doi = "10.1016/j.tvjl.2015.12.008",

language = "English",

volume = "210",

pages = "85--88",

journal = "The Veterinary Journal",

issn = "1090-0233",

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T1 - Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells

AU - Claessen, Christophe

AU - De Lange, Valérie

AU - Huang, Teng

AU - Ma, Guanggang

AU - Osterrieder, Nikolaus

AU - Favoreel, Herman

AU - Van de Walle, Gerlinde R.

PY - 2016/4

Y1 - 2016/4

N2 - Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data indicate that EHV1 employs different and still unresolved mechanisms to induce down-regulation of several functionally important cell surface proteins on equine DC.

AB - Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data indicate that EHV1 employs different and still unresolved mechanisms to induce down-regulation of several functionally important cell surface proteins on equine DC.

KW - Down-regulation

KW - Equine herpesvirus 1

KW - Monocyte-derived dendritic cells

KW - PUL56

KW - Down-regulation

KW - Equine herpesvirus 1

KW - Monocyte-derived dendritic cells

KW - PUL56

KW - Down-regulation

KW - Equine herpesvirus 1

KW - Monocyte-derived dendritic cells

KW - PUL56

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U2 - 10.1016/j.tvjl.2015.12.008

DO - 10.1016/j.tvjl.2015.12.008

M3 - RGC 21 - Publication in refereed journal

C2 - 26920348

SN - 1090-0233

VL - 210

SP - 85

EP - 88

JO - The Veterinary Journal

JF - The Veterinary Journal

ER -

Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells

Abstract

Research Keywords

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