TY - JOUR
T1 - Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells
AU - Claessen, Christophe
AU - De Lange, Valérie
AU - Huang, Teng
AU - Ma, Guanggang
AU - Osterrieder, Nikolaus
AU - Favoreel, Herman
AU - Van de Walle, Gerlinde R.
PY - 2016/4
Y1 - 2016/4
N2 - Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data indicate that EHV1 employs different and still unresolved mechanisms to induce down-regulation of several functionally important cell surface proteins on equine DC.
AB - Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data indicate that EHV1 employs different and still unresolved mechanisms to induce down-regulation of several functionally important cell surface proteins on equine DC.
KW - Down-regulation
KW - Equine herpesvirus 1
KW - Monocyte-derived dendritic cells
KW - PUL56
KW - Down-regulation
KW - Equine herpesvirus 1
KW - Monocyte-derived dendritic cells
KW - PUL56
KW - Down-regulation
KW - Equine herpesvirus 1
KW - Monocyte-derived dendritic cells
KW - PUL56
UR - http://www.scopus.com/inward/record.url?scp=84961614004&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84961614004&origin=recordpage
U2 - 10.1016/j.tvjl.2015.12.008
DO - 10.1016/j.tvjl.2015.12.008
M3 - RGC 21 - Publication in refereed journal
C2 - 26920348
SN - 1090-0233
VL - 210
SP - 85
EP - 88
JO - The Veterinary Journal
JF - The Veterinary Journal
ER -