Equine arteritis virus

Udeni B.R. Balasuriya; Yun Young Go; N. James MacLachlan

doi:10.1016/j.vetmic.2013.06.015

Equine arteritis virus

Udeni B.R. Balasuriya^*, Yun Young Go, N. James MacLachlan

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

86 Citations (Scopus)

Abstract

Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids. There has been significant recent progress in understanding the molecular biology of EAV and the pathogenesis of its infection in horses. In particular, the use of contemporary genomic techniques, along with the development and reverse genetic manipulation of infectious cDNA clones of several strains of EAV, has generated significant novel information regarding the basic molecular biology of the virus. Therefore, the objective of this review is to summarize current understanding of EAV virion architecture, replication, evolution, molecular epidemiology and genetic variation, pathogenesis including the influence of host genetics on disease susceptibility, host immune response, and potential vaccination and treatment strategies.

Original language	English
Pages (from-to)	93-122
Journal	Veterinary Microbiology
Volume	167
Issue number	1-2
Online published	3 Jul 2013
DOIs	https://doi.org/10.1016/j.vetmic.2013.06.015
Publication status	Published - 29 Nov 2013
Externally published	Yes

Research Keywords

EAV
Equine arteritis virus
EVA

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10.1016/j.vetmic.2013.06.015

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title = "Equine arteritis virus",

abstract = "Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids. There has been significant recent progress in understanding the molecular biology of EAV and the pathogenesis of its infection in horses. In particular, the use of contemporary genomic techniques, along with the development and reverse genetic manipulation of infectious cDNA clones of several strains of EAV, has generated significant novel information regarding the basic molecular biology of the virus. Therefore, the objective of this review is to summarize current understanding of EAV virion architecture, replication, evolution, molecular epidemiology and genetic variation, pathogenesis including the influence of host genetics on disease susceptibility, host immune response, and potential vaccination and treatment strategies. ",

keywords = "EAV, Equine arteritis virus, EVA",

author = "Balasuriya, {Udeni B.R.} and Go, {Yun Young} and MacLachlan, {N. James}",

year = "2013",

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day = "29",

doi = "10.1016/j.vetmic.2013.06.015",

language = "English",

volume = "167",

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journal = "Veterinary Microbiology",

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publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Equine arteritis virus

AU - Balasuriya, Udeni B.R.

AU - Go, Yun Young

AU - MacLachlan, N. James

PY - 2013/11/29

Y1 - 2013/11/29

N2 - Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids. There has been significant recent progress in understanding the molecular biology of EAV and the pathogenesis of its infection in horses. In particular, the use of contemporary genomic techniques, along with the development and reverse genetic manipulation of infectious cDNA clones of several strains of EAV, has generated significant novel information regarding the basic molecular biology of the virus. Therefore, the objective of this review is to summarize current understanding of EAV virion architecture, replication, evolution, molecular epidemiology and genetic variation, pathogenesis including the influence of host genetics on disease susceptibility, host immune response, and potential vaccination and treatment strategies.

AB - Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory and reproductive disease of equids. There has been significant recent progress in understanding the molecular biology of EAV and the pathogenesis of its infection in horses. In particular, the use of contemporary genomic techniques, along with the development and reverse genetic manipulation of infectious cDNA clones of several strains of EAV, has generated significant novel information regarding the basic molecular biology of the virus. Therefore, the objective of this review is to summarize current understanding of EAV virion architecture, replication, evolution, molecular epidemiology and genetic variation, pathogenesis including the influence of host genetics on disease susceptibility, host immune response, and potential vaccination and treatment strategies.

KW - EAV

KW - Equine arteritis virus

KW - EVA

UR - http://www.scopus.com/inward/record.url?scp=84889089738&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84889089738&origin=recordpage

U2 - 10.1016/j.vetmic.2013.06.015

DO - 10.1016/j.vetmic.2013.06.015

M3 - RGC 21 - Publication in refereed journal

C2 - 23891306

SN - 0378-1135

VL - 167

SP - 93

EP - 122

JO - Veterinary Microbiology

JF - Veterinary Microbiology

IS - 1-2

ER -

Equine arteritis virus

Abstract

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