Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Rong Zhang
  • Ning Dong
  • Zhangqi Shen
  • Yu Zeng
  • Jiauyue Lu
  • Congcong Liu
  • Hongwei Zhou
  • Yanyan Hu
  • Qiaoling Sun
  • Qipeng Cheng
  • Lingbing Shu
  • Jiachang Cai
  • Gongxiang Chen

Detail(s)

Original languageEnglish
Article number4648
Journal / PublicationNature Communications
Volume11
Online published16 Sep 2020
Publication statusPublished - 2020

Link(s)

Abstract

Emergence of tigecycline-resistance tet(X) gene orthologues rendered tigecycline ineffective as last-resort antibiotic. To understand the potential origin and transmission mechanisms of these genes, we survey the prevalence of tet(X) and its orthologues in 2997 clinical E. coli and K. pneumoniae isolates collected nationwide in China with results showing very low prevalence on these two types of strains, 0.32% and 0%, respectively. Further surveillance of tet(X) orthologues in 3692 different clinical Gram-negative bacterial strains collected during 1994-2019 in hospitals in Zhejiang province, China reveals 106 (2.7%) tet(X)-bearing strains with Flavobacteriaceae being the dominant (97/376, 25.8%) bacteria. In addition, tet(X)s are found to be predominantly located on the chromosomes of Flavobacteriaceae and share similar GC-content as Flavobacteriaceae. It also further evolves into different orthologues and transmits among different species. Data from this work suggest that Flavobacteriaceae could be the potential ancestral source of the tigecycline resistance gene tet(X).

Research Area(s)

Citation Format(s)

Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X). / Zhang, Rong; Dong, Ning; Shen, Zhangqi; Zeng, Yu; Lu, Jiauyue; Liu, Congcong; Zhou, Hongwei; Hu, Yanyan; Sun, Qiaoling; Cheng, Qipeng; Shu, Lingbing; Cai, Jiachang; Chan, Edward Wai-Chi; Chen, Gongxiang; Chen, Sheng.

In: Nature Communications, Vol. 11, 4648, 2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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