Entorhinohippocampal cholecystokinin modulates spatial learning by facilitating neuroplasticity of hippocampal CA3-CA1 synapses
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
---|---|
Article number | 113467 |
Journal / Publication | Cell Reports |
Volume | 42 |
Issue number | 12 |
Online published | 17 Nov 2023 |
Publication status | Published - 26 Dec 2023 |
Link(s)
DOI | DOI |
---|---|
Attachment(s) | Documents
Publisher's Copyright Statement
|
Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85177056700&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(6b7f753f-e874-42f8-8cb5-d1b777325597).html |
Abstract
The hippocampus is broadly impacted by neuromodulations. However, how neuropeptides shape the function of the hippocampus and the related spatial learning and memory remains unclear. Here, we discover the crucial role of cholecystokinin (CCK) in heterosynaptic neuromodulation from the medial entorhinal cortex (MEC) to the hippocampus. Systematic knockout of the CCK gene impairs CA3-CA1 LTP and space-related performance. The MEC provides most of the CCK-positive neurons projecting to the hippocampal region, which potentiates CA3-CA1 long-term plasticity heterosynaptically in a frequency- and NMDA receptor (NMDAR)-dependent manner. Selective inhibition of MEC CCKergic neurons or downregulation of their CCK mRNA levels also impairs CA3-CA1 LTP formation and animals’ performance in the water maze. This excitatory extrahippocampal projection releases CCK upon high-frequency excitation and is active during animal exploration. Our results reveal the critical role of entorhinal CCKergic projections in bridging intra- and extrahippocampal circuitry at electrophysiological and behavioral levels. © 2023 The Author(s).
Research Area(s)
- cholecystokinin, CP: Neuroscience, heterosynaptic plasticity, long-term potentiation, neuromodulation, spatial memory
Citation Format(s)
Entorhinohippocampal cholecystokinin modulates spatial learning by facilitating neuroplasticity of hippocampal CA3-CA1 synapses. / Su, Junfeng; Huang, Fengwen; Tian, Yu et al.
In: Cell Reports, Vol. 42, No. 12, 113467, 26.12.2023.
In: Cell Reports, Vol. 42, No. 12, 113467, 26.12.2023.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Download Statistics
No data available