Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs

Ran Xiao; Jiaheng Li; Yue Fung Wong; Lok Ting Chu; Yingxin Zhu; Liqiang Wang; Minghui Wu; Dingkun Zhang; Meng Gong; Joseph Lai; Kannie W. Y. Chan; Rong Fan; Ting-Hsuan Chen; Yang Lu

doi:10.1038/s44172-024-00185-5

Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs

Ran Xiao, Jiaheng Li, Yue Fung Wong, Lok Ting Chu, Yingxin Zhu, Liqiang Wang, Minghui Wu, Dingkun Zhang, Meng Gong, Joseph Lai, Kannie W. Y. Chan, Rong Fan^*, Ting-Hsuan Chen^*, Yang Lu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Abstract

Nasopharyngeal (NP) swab is one of the most effective sampling devices for clinical specimens. However, commercial NP swabs often release samples through diluents, lowering analyte concentration and causing inaccurate detections. Here, we developed 3D-printed open-cell microlattice NP swabs with user-friendly high-efficiency controlled sample release (CR) mode. Compared with traditional NP swabs, our microlattice NP swabs show higher (~7–11 times) flexibility, larger (~2.3 times) and customizable release volume, higher (dozens to thousands of times) release concentration, high recovery efficiency (~100%), and the ability to quantify analyte levels. Our microlattice NP swabs have been thus demonstrated to improve the sensitivity and accuracy of antibody detection experiments using rapid detection kits. This study offers a promising approach to enhance sensitivity and accuracy in clinical specimen detections, and is beneficial to inspire the design of a wider range of biomedical devices based on 3D-printed microlattice metamaterials. © The Author(s) 2024.

Original language	English
Article number	40
Journal	Communications Engineering
Volume	3
Online published	4 Mar 2024
DOIs	https://doi.org/10.1038/s44172-024-00185-5
Publication status	Published - 2024

Funding

Innovation and Technology Commission grants No. ITS/098/20 and No. GHP/221/21GD. The Science and Technology Department of Sichuan Province grant No. 2022YFSY0001. Changsha Municipal Science and Technology Bureau project grant No. kh2201035. Shenzhen-Hong Kong-Macau Science and Technology Program grant Category C, No. SGDX2020110309300301. The University of Hong Kong (HKU) Seed Fund for Collaborative Research No. 109000410.

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This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

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ITF: Preparation of High Performance Environmental Barrier Coatings (EBCs) on Femtosecond Laser Textured-Matrix and their Multi-Scale Mechanical Characterization
WANG, S. (Principal Investigator / Project Coordinator), FAN, R. (Co-Investigator) & FAN, Z. (Co-Investigator)
1/07/23 → 30/06/25
Project: Research
ITF: Fingerstick Blood Test for Quantitative Detection of Immunity Against COVID-19
CHEN, T. H. (Principal Investigator / Project Coordinator), CHU, L. T. (Co-Investigator) & WU, S. (Co-Investigator)
1/06/21 → 30/11/22
Project: Research

Cite this

@article{5cdad1ccfad7402397888a043d7640d8,

title = "Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs",

abstract = "Nasopharyngeal (NP) swab is one of the most effective sampling devices for clinical specimens. However, commercial NP swabs often release samples through diluents, lowering analyte concentration and causing inaccurate detections. Here, we developed 3D-printed open-cell microlattice NP swabs with user-friendly high-efficiency controlled sample release (CR) mode. Compared with traditional NP swabs, our microlattice NP swabs show higher (~7–11 times) flexibility, larger (~2.3 times) and customizable release volume, higher (dozens to thousands of times) release concentration, high recovery efficiency (~100%), and the ability to quantify analyte levels. Our microlattice NP swabs have been thus demonstrated to improve the sensitivity and accuracy of antibody detection experiments using rapid detection kits. This study offers a promising approach to enhance sensitivity and accuracy in clinical specimen detections, and is beneficial to inspire the design of a wider range of biomedical devices based on 3D-printed microlattice metamaterials. {\textcopyright} The Author(s) 2024.",

author = "Ran Xiao and Jiaheng Li and Wong, {Yue Fung} and Chu, {Lok Ting} and Yingxin Zhu and Liqiang Wang and Minghui Wu and Dingkun Zhang and Meng Gong and Joseph Lai and Chan, {Kannie W. Y.} and Rong Fan and Ting-Hsuan Chen and Yang Lu",

year = "2024",

doi = "10.1038/s44172-024-00185-5",

language = "English",

volume = "3",

}

TY - JOUR

T1 - Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs

AU - Xiao, Ran

AU - Li, Jiaheng

AU - Wong, Yue Fung

AU - Chu, Lok Ting

AU - Zhu, Yingxin

AU - Wang, Liqiang

AU - Wu, Minghui

AU - Zhang, Dingkun

AU - Gong, Meng

AU - Lai, Joseph

AU - Chan, Kannie W. Y.

AU - Fan, Rong

AU - Chen, Ting-Hsuan

AU - Lu, Yang

PY - 2024

Y1 - 2024

N2 - Nasopharyngeal (NP) swab is one of the most effective sampling devices for clinical specimens. However, commercial NP swabs often release samples through diluents, lowering analyte concentration and causing inaccurate detections. Here, we developed 3D-printed open-cell microlattice NP swabs with user-friendly high-efficiency controlled sample release (CR) mode. Compared with traditional NP swabs, our microlattice NP swabs show higher (~7–11 times) flexibility, larger (~2.3 times) and customizable release volume, higher (dozens to thousands of times) release concentration, high recovery efficiency (~100%), and the ability to quantify analyte levels. Our microlattice NP swabs have been thus demonstrated to improve the sensitivity and accuracy of antibody detection experiments using rapid detection kits. This study offers a promising approach to enhance sensitivity and accuracy in clinical specimen detections, and is beneficial to inspire the design of a wider range of biomedical devices based on 3D-printed microlattice metamaterials. © The Author(s) 2024.

AB - Nasopharyngeal (NP) swab is one of the most effective sampling devices for clinical specimens. However, commercial NP swabs often release samples through diluents, lowering analyte concentration and causing inaccurate detections. Here, we developed 3D-printed open-cell microlattice NP swabs with user-friendly high-efficiency controlled sample release (CR) mode. Compared with traditional NP swabs, our microlattice NP swabs show higher (~7–11 times) flexibility, larger (~2.3 times) and customizable release volume, higher (dozens to thousands of times) release concentration, high recovery efficiency (~100%), and the ability to quantify analyte levels. Our microlattice NP swabs have been thus demonstrated to improve the sensitivity and accuracy of antibody detection experiments using rapid detection kits. This study offers a promising approach to enhance sensitivity and accuracy in clinical specimen detections, and is beneficial to inspire the design of a wider range of biomedical devices based on 3D-printed microlattice metamaterials. © The Author(s) 2024.

U2 - 10.1038/s44172-024-00185-5

DO - 10.1038/s44172-024-00185-5

M3 - RGC 21 - Publication in refereed journal

VL - 3

JO - Communications Engineering

JF - Communications Engineering

M1 - 40

ER -

Enhancing detection accuracy via controlled release of 3D-printed microlattice nasopharyngeal swabs

Abstract

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Projects

ITF: Preparation of High Performance Environmental Barrier Coatings (EBCs) on Femtosecond Laser Textured-Matrix and their Multi-Scale Mechanical Characterization

ITF: Fingerstick Blood Test for Quantitative Detection of Immunity Against COVID-19

Cite this