Enhanced hydroxyapatite growth and osteogenic activity on polydopamine coated Ti implants

Xiang Xiao; Yao Xu; Jijiang Fu; Biao Gao; Kaifu Huo; Paul K. Chu

doi:10.1166/nnl.2015.1965

Enhanced hydroxyapatite growth and osteogenic activity on polydopamine coated Ti implants

Xiang Xiao, Yao Xu, Jijiang Fu, Biao Gao, Kaifu Huo, Paul K. Chu

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

14 Citations (Scopus)

Abstract

Titanium (Ti) and its alloy are widely used in biomedical implant but the poor bioactivity of Ti restricts some direct applications. Polydopamine (PDA), a functional polymeric substance mimicking the mussel adhesive protein, is deposited on Ti surface to improve the bioactivity by means of a mild and facile technique employing an alkaline dopamine solution. The PDA coated Ti implant accelerates nucleation and growth of hydroxyapatite (HAP), enhances osteoblast cell adhesion and proliferation, and improves the ALP activity thus having promising biomedical applications.

Original language	English
Pages (from-to)	233-239
Journal	Nanoscience and Nanotechnology Letters
Volume	7
Issue number	3
DOIs	https://doi.org/10.1166/nnl.2015.1965
Publication status	Published - 1 Mar 2015

Research Keywords

Bioactivity
Hydroxyapatite
Osteoblasts
Polydopamine
Titanium

Access Output

10.1166/nnl.2015.1965

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{4938401e1fcb44e68e87c9ce06fe54b2,

title = "Enhanced hydroxyapatite growth and osteogenic activity on polydopamine coated Ti implants",

abstract = "Titanium (Ti) and its alloy are widely used in biomedical implant but the poor bioactivity of Ti restricts some direct applications. Polydopamine (PDA), a functional polymeric substance mimicking the mussel adhesive protein, is deposited on Ti surface to improve the bioactivity by means of a mild and facile technique employing an alkaline dopamine solution. The PDA coated Ti implant accelerates nucleation and growth of hydroxyapatite (HAP), enhances osteoblast cell adhesion and proliferation, and improves the ALP activity thus having promising biomedical applications.",

keywords = "Bioactivity, Hydroxyapatite, Osteoblasts, Polydopamine, Titanium",

author = "Xiang Xiao and Yao Xu and Jijiang Fu and Biao Gao and Kaifu Huo and Chu, {Paul K.}",

year = "2015",

month = mar,

day = "1",

doi = "10.1166/nnl.2015.1965",

language = "English",

volume = "7",

pages = "233--239",

journal = "Nanoscience and Nanotechnology Letters",

issn = "1941-4900",

publisher = "American Scientific Publishers",

number = "3",

}

TY - JOUR

T1 - Enhanced hydroxyapatite growth and osteogenic activity on polydopamine coated Ti implants

AU - Xiao, Xiang

AU - Xu, Yao

AU - Fu, Jijiang

AU - Gao, Biao

AU - Huo, Kaifu

AU - Chu, Paul K.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Titanium (Ti) and its alloy are widely used in biomedical implant but the poor bioactivity of Ti restricts some direct applications. Polydopamine (PDA), a functional polymeric substance mimicking the mussel adhesive protein, is deposited on Ti surface to improve the bioactivity by means of a mild and facile technique employing an alkaline dopamine solution. The PDA coated Ti implant accelerates nucleation and growth of hydroxyapatite (HAP), enhances osteoblast cell adhesion and proliferation, and improves the ALP activity thus having promising biomedical applications.

AB - Titanium (Ti) and its alloy are widely used in biomedical implant but the poor bioactivity of Ti restricts some direct applications. Polydopamine (PDA), a functional polymeric substance mimicking the mussel adhesive protein, is deposited on Ti surface to improve the bioactivity by means of a mild and facile technique employing an alkaline dopamine solution. The PDA coated Ti implant accelerates nucleation and growth of hydroxyapatite (HAP), enhances osteoblast cell adhesion and proliferation, and improves the ALP activity thus having promising biomedical applications.

KW - Bioactivity

KW - Hydroxyapatite

KW - Osteoblasts

KW - Polydopamine

KW - Titanium

UR - http://www.scopus.com/inward/record.url?scp=84929847007&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-84929847007&origin=recordpage

U2 - 10.1166/nnl.2015.1965

DO - 10.1166/nnl.2015.1965

M3 - RGC 21 - Publication in refereed journal

SN - 1941-4900

VL - 7

SP - 233

EP - 239

JO - Nanoscience and Nanotechnology Letters

JF - Nanoscience and Nanotechnology Letters

IS - 3

ER -

Enhanced hydroxyapatite growth and osteogenic activity on polydopamine coated Ti implants

Abstract

Research Keywords

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Cite this