Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study

Gurpreet K. Dhindsa; Debsindhu Bhowmik; Monojoy Goswami; Hugh O'Neill; Eugene Mamontov; Bobby G. Sumpter; Liang Hong; Panchapakesan Ganesh; Xiang-Qiang Chu

doi:10.1021/acs.jpcb.6b07511

Author(s)

Gurpreet K. Dhindsa
Debsindhu Bhowmik
Monojoy Goswami
Hugh O'Neill
Eugene Mamontov
Bobby G. Sumpter
Liang Hong
Panchapakesan Ganesh

Detail(s)

Original language	English
Pages (from-to)	10059-10068
Journal / Publication	The Journal of Physical Chemistry B
Volume	120
Issue number	38
Publication status	Published - 29 Sept 2016
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1021/acs.jpcb.6b07511 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84992172136&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(0a48ab37-30f4-4ca1-a495-498a6ccd58e4).html

Abstract

Nontoxic, biocompatible nanodiamonds (ND) have recently been implemented in rational, systematic design of optimal therapeutic use in nanomedicines. However, hydrophilicity of the ND surface strongly influences structure and dynamics of biomolecules that restrict in situ applications of ND. Therefore, fundamental understanding of the impact of hydrophilic ND surface on biomolecules at the molecular level is essential. For tRNA, we observe an enhancement of dynamical behavior in the presence of ND contrary to generally observed slow motion at strongly interacting interfaces. We took advantage of neutron scattering experiments and computer simulations to demonstrate this atypical faster dynamics of tRNA on ND surface. The strong attractive interactions between ND, tRNA, and water give rise to unlike dynamical behavior and structural changes of tRNA in front of ND compared to without ND. Our new findings may provide new design principles for safer, improved drug delivery platforms.

Bibliographic Note

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Citation Format(s)

[ RIS ] [ BibTeX ]

Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study. / Dhindsa, Gurpreet K.; Bhowmik, Debsindhu; Goswami, Monojoy et al.
In: The Journal of Physical Chemistry B, Vol. 120, No. 38, 29.09.2016, p. 10059-10068.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Dhindsa, GK, Bhowmik, D, Goswami, M, O'Neill, H, Mamontov, E, Sumpter, BG, Hong, L, Ganesh, P & Chu, X-Q 2016, 'Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study', The Journal of Physical Chemistry B, vol. 120, no. 38, pp. 10059-10068. https://doi.org/10.1021/acs.jpcb.6b07511

Dhindsa, G. K., Bhowmik, D., Goswami, M., O'Neill, H., Mamontov, E., Sumpter, B. G., Hong, L., Ganesh, P., & Chu, X.-Q. (2016). Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study. The Journal of Physical Chemistry B, 120(38), 10059-10068. https://doi.org/10.1021/acs.jpcb.6b07511

Dhindsa GK, Bhowmik D, Goswami M, O'Neill H, Mamontov E, Sumpter BG et al. Enhanced dynamics of hydrated tRNA on nanodiamond surfaces: A combined neutron scattering and MD simulation study. The Journal of Physical Chemistry B. 2016 Sept 29;120(38):10059-10068. doi: 10.1021/acs.jpcb.6b07511

Dhindsa, Gurpreet K. ; Bhowmik, Debsindhu ; Goswami, Monojoy et al. / Enhanced dynamics of hydrated tRNA on nanodiamond surfaces : A combined neutron scattering and MD simulation study. In: The Journal of Physical Chemistry B. 2016 ; Vol. 120, No. 38. pp. 10059-10068.

Enhanced dynamics of hydrated tRNA on nanodiamond surfaces : A combined neutron scattering and MD simulation study