Enhanced dynamics of hydrated tRNA on nanodiamond surfaces : A combined neutron scattering and MD simulation study

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

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Author(s)

  • Gurpreet K. Dhindsa
  • Debsindhu Bhowmik
  • Monojoy Goswami
  • Hugh O'Neill
  • Eugene Mamontov
  • Bobby G. Sumpter
  • Liang Hong
  • Panchapakesan Ganesh

Detail(s)

Original languageEnglish
Pages (from-to)10059-10068
Journal / PublicationJournal of Physical Chemistry B
Volume120
Issue number38
Publication statusPublished - 29 Sep 2016
Externally publishedYes

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-84992172136&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(0a48ab37-30f4-4ca1-a495-498a6ccd58e4).html

Abstract

Nontoxic, biocompatible nanodiamonds (ND) have recently been implemented in rational, systematic design of optimal therapeutic use in nanomedicines. However, hydrophilicity of the ND surface strongly influences structure and dynamics of biomolecules that restrict in situ applications of ND. Therefore, fundamental understanding of the impact of hydrophilic ND surface on biomolecules at the molecular level is essential. For tRNA, we observe an enhancement of dynamical behavior in the presence of ND contrary to generally observed slow motion at strongly interacting interfaces. We took advantage of neutron scattering experiments and computer simulations to demonstrate this atypical faster dynamics of tRNA on ND surface. The strong attractive interactions between ND, tRNA, and water give rise to unlike dynamical behavior and structural changes of tRNA in front of ND compared to without ND. Our new findings may provide new design principles for safer, improved drug delivery platforms.

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Citation Format(s)

[ RIS ] [ BibTeX ]

Enhanced dynamics of hydrated tRNA on nanodiamond surfaces : A combined neutron scattering and MD simulation study. / Dhindsa, Gurpreet K.; Bhowmik, Debsindhu; Goswami, Monojoy et al.

In: Journal of Physical Chemistry B, Vol. 120, No. 38, 29.09.2016, p. 10059-10068.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review