Enhanced cytocompatibility of silver-containing biointerface by constructing nitrogen functionalities

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

5 Scopus Citations
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Author(s)

  • Wei Zhang
  • Jun Liu
  • Huaiyu Wang
  • Ying Xu
  • Pingli Wang
  • Junhui Ji

Detail(s)

Original languageEnglish
Pages (from-to)327-332
Journal / PublicationApplied Surface Science
Volume349
Publication statusPublished - 15 Sep 2015

Abstract

Silver (Ag) has recently been introduced into polymeric biomedical implants by plasma immersion ion implantation (PIII) to enhance the antibacterial capability. However, Ag ions and nanoparticles can increase the cytotoxicity and inhibit cellular proliferation and the relationship is time- and dose-dependent. In this study, Ag and N2 PIII is conducted in concert to produce nitrogen functional groups as well as Ag-containing biointerface. In addition to the creation of nitrogen functionalities, the surface roughness and hydrophilicity are improved in favor of protein adsorption. Compared to the biointerface created by Ag PIII only, the nitrogen functionalities generated by N2 co-PIII do not affect DNA synthesis and the total protein level but evidently enhance cellular adhesion, viability, and proliferation at the biointerface. The modified surface is observed to upregulate the osteogenesis-related marker expression of bone cells in contact. Our findings suggest that dual Ag and N2 PIII is a desirable technique to enhance both the cytocompatibility and antibacterial capability of medical polymers.

Research Area(s)

  • Antibacterial capability, Cytocompatibility, N<inf>2</inf> plasma immersion ion implantation, Polymeric implant, Silver

Citation Format(s)

Enhanced cytocompatibility of silver-containing biointerface by constructing nitrogen functionalities. / Zhang, Wei; Liu, Jun; Wang, Huaiyu; Xu, Ying; Wang, Pingli; Ji, Junhui; Chu, Paul K.

In: Applied Surface Science, Vol. 349, 15.09.2015, p. 327-332.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review