Enhanced cytocompatibility and reduced genotoxicity of polydimethylsiloxane modified by plasma immersion ion implantation

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

6 Scopus Citations
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Author(s)

  • Liping Tong
  • Wenhua Zhou
  • Yuetao Zhao
  • Xuefeng Yu
  • Huaiyu Wang

Detail(s)

Original languageEnglish
Pages (from-to)139-146
Journal / PublicationColloids and Surfaces B: Biointerfaces
Volume148
Online published31 Aug 2016
Publication statusPublished - 1 Dec 2016

Abstract

Polydimethylsiloxane(PDMS) is a common industrial polymer with advantages such as ease of fabrication, tunable hardness, and other desirable properties, but the basic (-OSi(CH3)2-)n structure in PDMS is inherently hydrophobic thereby hampering application to biomedical engineering. In this study, plasma immersion ion implantation (PIII) is conducted on PDMS to improve the biological properties. PIII forms wrinkled “herringbone” patterns and abundant O-containing functional groups on PDMS to alter the surface hydrophilicity. The biocompatibility of the modified PDMS is assessed with Chinese hamster ovarian cells and compared to that of the untreated PDMS. Our results reveal that the PDMS samples after undergoing PIII have better cytocompatibility and lower genotoxicity. PIII which is a non-line-of-sight technique extends the application of PDMS to the biomedical field.

Research Area(s)

  • Biocompatibility, Genotoxicity, Plasma immersion ion implantation, Polydimethylsiloxane, Surface modification

Citation Format(s)

Enhanced cytocompatibility and reduced genotoxicity of polydimethylsiloxane modified by plasma immersion ion implantation. / Tong, Liping; Zhou, Wenhua; Zhao, Yuetao; Yu, Xuefeng; Wang, Huaiyu; Chu, Paul K.

In: Colloids and Surfaces B: Biointerfaces, Vol. 148, 01.12.2016, p. 139-146.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review